Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Neuronal Reprogramming: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Neuroferroptosis | involved_in | process | 0.75 |
| Ferroptosis | involved_in | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Partial Neuronal Reprogramming via Modified Yamanaka Cocktai | 0.672 | neurodegeneration | Epigenetic reprogramming in aging neuron |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| AAV-LRRK2 IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| CRISPR Gene Correction Approaches for CBS/PSP | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| AAV-LRRK2 Gene Therapy IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Engineered LINC MIR503HG-loaded extracellular vesicles maintain stemness and plu [PMID:41551196] | Zhu J, Zhu X, Feng W, Jin Y, Ge X et al. | Bioact Mater | 2026 | 0 |
| Development of a practical GMP-compliant manufacturing process for T cell-derive [PMID:41691922] | Hulspas R, Sasso C, Cunningham A, Cancel | Cytotherapy | 2026 | 0 |
| Establishment of a human induced pluripotent stem cell line (BTHBIOi005-A) from [PMID:41713384] | Liu ZY, Zhang H, Zhang XH, Shen RJ, Jin | Stem Cell Res | 2026 | 0 |
| Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Re [PMID:38381405] | Macip CC, Hasan R, Hoznek V, Kim J, Lu Y | Cellular reprogramming | 2024 | 0 |
| Targeted partial reprogramming of age-associated cell states improves markers of [PMID:39259812] | Sahu SK, Reddy P, Lu J, Shao Y, Wang C, | Science translational medicine | 2024 | 0 |
| Development of a clinical polygenic risk score assay and reporting workflow. [PMID:35437332] | ["Hao L", "Kraft P", "Berriz G", "Hynes | Nature medicine | 2022 | 0 |
| Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mi [PMID:33268894] | ["Karigo T", "Kennedy A", "Yang B", "Liu | Nature | 2021 | 0 |
| Predicting ambient PM [PMID:32747729] | ["Enebish T", "Chau K", "Jadamba B", "Fr | Journal of exposure science & | 2021 | 0 |
| Correction: MicroRNA signatures of TRAIL resistance in human non-small cell lung [PMID:33398039] | M Garofalo; C Quintavalle; G Di Leva; C | Oncogene | 2021 | 0 |
| Mechanisms of OCT4-SOX2 motif readout on nucleosomes. [PMID:32327602] | Michael AK, Grand RS, Isbel L, Cavadini | Science (New York, N.Y.) | 2020 | 0 |
| The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish [PMID:32664640] | Biava PM | International journal of molec | 2020 | 0 |
| Tumour lineage shapes BRCA-mediated phenotypes. [PMID:31292550] | ["Jonsson P", "Bandlamudi C", "Cheng M", | Nature | 2019 | 0 |
| Cooperative Binding of Transcription Factors Orchestrates Reprogramming. [PMID:28111071] | Chronis C, Fiziev P, Papp B, Butz S, Bon | Cell | 2017 | 0 |
| Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. [PMID:28877458] | ["Newman J", "Covarrubias A", "Zhao M", | Cell metabolism | 2017 | 0 |
| In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. [PMID:27984723] | ["Ocampo A", "Reddy P", "Martinez-Redond | Cell | 2016 | 0 |
| Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman pr [PMID:25297091] | ["Forny-Germano L", "Lyra e Silva N", "B | The Journal of neuroscience : | 2014 | 0 |
| Structure and interactions of the human programmed cell death 1 receptor. [PMID:23417675] | ["Cheng X", "Veverka V", "Radhakrishnan | The Journal of biological chem | 2013 | 0 |
| Location and cellular stages of natural killer cell development. [PMID:24055329] | ["Yu J", "Freud A", "Caligiuri M"] | Trends in immunology | 2013 | 0 |
| A molecular roadmap of reprogramming somatic cells into iPS cells. [PMID:23260147] | ["Polo J", "Anderssen E", "Walsh R", "Sc | Cell | 2012 | 0 |
| Direct conversion of fibroblasts into stably expandable neural stem cells. [PMID:22445518] | ["Thier M", "W\u00f6rsd\u00f6rfer P", "L | Cell stem cell | 2012 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity