Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ferroptosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ferroptosis is a biological pathway involved in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, Acute Kidney Injury, Aging. Connected to 1388 entities in the SciDEX knowledge graph.
| Name | Ferroptosis |
| Key Genes/Proteins | GPX4, SLC7A11, NRF2, BECN1, GENES |
| Related Diseases | Als, Cancer, Tumor |
| Linked Hypotheses | 10 hypotheses |
Knowledge base pages for this entity
graph TD
Ferroptosis["Ferroptosis"] -->|"interacts"| Pyroptosis["Pyroptosis"]
Ferroptosis["Ferroptosis"] -->|"interacts"| Apoptosis["Apoptosis"]
Ferroptosis["Ferroptosis"] -->|"interacts"| Complement["Complement"]
Ferroptosis["Ferroptosis"] -->|"interacts"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
JUN["JUN"] -->|"activates"| Ferroptosis["Ferroptosis"]
MIRO1["MIRO1"] -->|"activates"| Ferroptosis["Ferroptosis"]
TFR1["TFR1"] -->|"associated"| Ferroptosis["Ferroptosis"]
TFR1_1["TFR1"] -->|"contributes to"| Ferroptosis["Ferroptosis"]
style Ferroptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Iron | associated_with | compound | 0.95 |
| Autophagy | associated_with | process | 0.95 |
| Cell Death | causes | process | 0.95 |
| Regulated Cell Death | component_of | process | 0.95 |
| Iron Accumulation | causes | phenotype | 0.95 |
| Cell Death | mediates | process | 0.95 |
| Cell Death | involved_in | process | 0.95 |
| Chronic Kidney Disease | associated_with | disease | 0.95 |
| Acute Kidney Injury | associated_with | disease | 0.95 |
| Reactive Oxygen Species | causes | process | 0.95 |
| Cell Death | component_of | process | 0.95 |
| Intracerebral Hemorrhage | involved_in | disease | 0.95 |
| Cancer | inhibits | disease | 0.95 |
| Chronic Kidney Disease | involved_in | disease | 0.95 |
| Oxidative Stress | associated_with | process | 0.95 |
| Purkinje Cell Degeneration | causes | phenotype | 0.95 |
| Lipid Hydroperoxides | mediates | compound | 0.95 |
| Degenerative Diseases | associated_with | disease | 0.95 |
| Malignancies | associated_with | disease | 0.95 |
| Phospholipid Peroxidation | associated_with | mechanism | 0.95 |
| Iron-Dependent Lipid Peroxidation | mediates | mechanism | 0.95 |
| Iron Overload | associated_with | phenotype | 0.95 |
| Septic Cardiomyopathy | contributes_to | disease | 0.95 |
| Cerebral Ischemia/Reperfusion Injury | contributes_to | disease | 0.95 |
| Nerve cell damage | causes | phenotype | 0.95 |
| Dopaminergic Neurodegeneration | mediates | process | 0.95 |
| Mitochondrial Dysfunction | associated_with | process | 0.95 |
| Iron Accumulation | mediates | mechanism | 0.92 |
| Lipid Peroxidation | mediates | mechanism | 0.92 |
| Purkinje Cell Degeneration | mediates | phenotype | 0.92 |
| Cervical Cancer Cell Death | mediates | phenotype | 0.92 |
| Substantia Nigra Neurodegeneration | contributes_to | phenotype | 0.92 |
| Lactation Dysfunction | causes | phenotype | 0.90 |
| Myocardial Ischemia-Reperfusion Injury | contributes_to | disease | 0.90 |
| Apoptosis | associated_with | process | 0.90 |
| Pancreatic Cancer Cell Death | causes | phenotype | 0.90 |
| Cancer Cell Death | associated_with | phenotype | 0.90 |
| Lipid-ROS | causes | compound | 0.90 |
| Parkinson's Disease | contributes_to | disease | 0.90 |
| Cancer | associated_with | disease | 0.90 |
| Neurodegeneration | associated_with | disease | 0.90 |
| Ischemic Organ Injury | associated_with | disease | 0.90 |
| Cardiovascular Disease | associated_with | disease | 0.90 |
| Iron | involved_in | compound | 0.90 |
| Bovine Mastitis | associated_with | disease | 0.90 |
| Chronic Kidney Disease | contributes_to | disease | 0.90 |
| Acute Kidney Injury | contributes_to | disease | 0.90 |
| Chronic Kidney Disease | causes | disease | 0.90 |
| Cell Death | associated_with | process | 0.90 |
| Endothelial Cell Dysfunction | contributes_to | phenotype | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPX4 | inhibits | gene | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| SLC7A11 | inhibits | gene | 1.00 |
| BECN1 | activates | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| P53 | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| GENES | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| GPX4 | regulates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| FERROPTOSIS | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| FERROPTOSIS | inhibits | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Ferroptosis Inhibition for α-Synuclein Neuroprotection | 0.548 | neurodegeneration | Gene expression changes in aging mouse b |
| ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v | 0.491 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
immunology | 2026-04-15 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092] | Jiang H, Hu W, Yuan L | Tohoku J Exp Med | 2026 | 0 |
| GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] | Yang M, Bian F, Feng X, Li L, Huang H et | Mol Ther | 2026 | 0 |
| Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] | Liu J, Cai X, Lin J, Zhang Z, Zhou Q et | Cell | 2026 | 0 |
| Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] | Gromadzka G, Tarnacka B, Cieślik M | Int J Mol Sci | 2026 | 0 |
| Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] | Tuo QZ, Bush AI, Lei P | Mol Psychiatry | 2026 | 0 |
| Fin(e)-tuning ferroptosis. [PMID:41576911] | Szylo KJ, Dixon SJ | Mol Cell | 2026 | 0 |
| GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] | Liu G, Wang Y, Huang H, Wang J, Yang J e | Cell Mol Immunol | 2026 | 0 |
| A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] | Xia Z, Yang X, Samovich SN, Tyurina YY, | Cell | 2026 | 0 |
| The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] | Park WH | Pharmacol Res | 2026 | 0 |
| Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] | Song C, Liu Z, Tang J, Huang Y | Neuropsychiatr Dis Treat | 2026 | 0 |
| Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] | Chen X | Trends Mol Med | 2026 | 0 |
| 4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917] | Zhang S, Yue T, Jin P, Zhang X, Huo Q et | Free Radic Biol Med | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411] | Hao W, Sun N, Xue R, Chang J, Pang X et | ACS Appl Mater Interfaces | 2026 | 0 |
| Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797] | Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G | Adv Sci (Weinh) | 2026 | 0 |
| Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998] | Zayed M, Tayara H, Jeong BH | Redox Biol | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243] | Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L | Stem Cell Res Ther | 2026 | 0 |
| NOX4 mediates ferroptosis through oxidative stress in diabetic keratopathy. [PMID:41951167] | Wang X, Wang Y, Zhao X, Yu X, Qu Y et al | Exp Eye Res | 2026 | 0 |
| Targeting NDUFS4 Disrupts Oxidative Phosphorylation and Induces Ferroptosis in O [PMID:41954274] | Schaaf ZA, Ning S, Leslie AR, Sharifi M, | Mol Cancer Ther | 2026 | 0 |