Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P2RX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | P2RX6 |
| Full Name | Purinergic Receptor P2X Ligand-Gated Ion Channel 6 |
| Chromosome | 22q13.1 |
| Protein Family | P2X Receptor Family |
| Function | encodes the P2X receptor subunit 6, a member of the P2X ligand-gated ion channel family that responds to extracellular adenosine triphosphate (ATP) |
| Primary Expression | various tissues and plays important roles in immune function, neuromuscular signaling, and potentially in neurodegenerative diseases |
| Molecular Weight | 56 kDa |
| UniProt ID | Q9R9E9 |
| NCBI Gene ID | 63826 |
| Ensembl ID | ENSG00000099901 |
| OMIM | 607184 |
| GeneCards | P2RX6 |
| Human Protein Atlas | P2RX6 |
| N-terminal extracellular domain | Contains ATP binding sites |
| Two transmembrane domains | Form the channel pore |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
P2RX6["P2RX6"]
neurodegeneration["neurodegeneration"]
P2RX6 -->|"implicated_in"| neurodegeneration
style P2RX6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning P2RX6 in their description or question text
No additional research found