protein 1,024 words KG: P2RX6PROTEIN
Contents

P2RX6 Protein — Purinergic Receptor P2X Subunit 6

🔬 Protein Info
Gene SymbolP2RX6
Full NamePurinergic Receptor P2X Ligand-Gated Ion Channel 6
Chromosome22q13.1
Protein FamilyP2X Receptor Family
Functionencodes the P2X receptor subunit 6, a member of the P2X ligand-gated ion channel family that responds to extracellular adenosine triphosphate (ATP)
Primary Expressionvarious tissues and plays important roles in immune function, neuromuscular signaling, and potentially in neurodegenerative diseases
Subcellular Localization** | Plasma membrane, Endoplasmic reticulum |
Molecular Weight56 kDa
UniProt IDQ9R9E9
NCBI Gene ID63826
Ensembl IDENSG00000099901
OMIM607184
GeneCardsP2RX6
Human Protein AtlasP2RX6
O-glycosylation sitesUnique among P2X subunits
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (9)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36

Related Analyses (12)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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