protein

P38A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P38A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

p38 Alpha Protein

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🔬 Protein Info

Gene Symbol	P38A
Protein Family	p38 MAPK family
Protein Type	Serine/Threonine Kinase
Function	p38α is a serine/threonine kinase activated by cellular stress, cytokines, and inflammatory stimuli.
Primary Expression	neurons and glia and contributes to neuroinflammation, amyloid-beta production, and [tau](/entities/tau
Molecular Weight	41.3 kDa
UniProt ID	[Q16539](https://www.uniprot.org/uniprot/Q16539)
GeneCards	P38A
Human Protein Atlas	P38A
MAPK Pathway	ERK1/2, JNK, p38β, p38γ, p38δ
Upstream Kinases	MKK3, MKK6, TAB1, ASK1
Transcription Factors	ATF2, CREB, p53
Neurodegenerative Conditions	Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

p38 Alpha Protein

protein · 598 words

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Pathway Diagram

graph TD
    P38A["P38A"]
    neurodegeneration["neurodegeneration"]
    P38A -->|"implicated_in"| neurodegeneration
    style P38A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning P38A in their description or question text

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