protein

P62SQSTM1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about P62SQSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	P62SQSTM1
Protein Family	Selective autophagy receptors (SARs)
Protein Type	Scaffold Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	nearly all major neurodegenerative diseases, including [alzheimers](/diseases/al
Molecular Weight	~62 kDa
Amino Acids	440
UniProt ID	Q13501
GeneCards	P62SQSTM1
Human Protein Atlas	P62SQSTM1
[nf-kb](/entities/nf-kb) activation	Through TRAF6 and RIP1 recruitment, p62 activates pro-inflammatory nf-kb signaling in response to IL-1, TNF-alpha, and NGF
Nrf2 antioxidant response	Accumulated p62 sequesters Keap1, releasing nrf2 to translocate to the nucleus and activate antioxidant gene expression (Komatsu et al., 2010)
mTORC1 regulation	p62 recruits mTORC1 to lysosomal membranes via Raptor binding, promoting mtor-neurodegeneration activation and anabolic signaling
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: P62SQSTM1 — AlphaFold Q13501 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

p62/SQSTM1

protein · 1232 words

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Pathway Diagram

graph TD
    P62SQSTM1["P62SQSTM1"]
    neurodegeneration["neurodegeneration"]
    P62SQSTM1 -->|"implicated_in"| neurodegeneration
    style P62SQSTM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Related Research

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