protein 1,232 words KG: P62SQSTM1 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

p62/SQSTM1

🔬 Protein Info
Gene SymbolP62SQSTM1
Protein FamilySelective autophagy receptors (SARs)
Protein TypeScaffold Protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationCytoplasm, autophagosomes, protein aggregates, nucleus
Molecular Weight~62 kDa
Amino Acids440
UniProt IDQ13501
GeneCardsP62SQSTM1
Human Protein AtlasP62SQSTM1
Genesqstm1
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Closed-loop tACS targeting entorhinal cortex layer II SST in
Score: 0.62
NLRP3/Mitophagy Coupling Modulation
Score: 0.52
Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Membrane Repair Enhancement
Score: 0.45

Related Analyses (5)

What determines the spatial organization of autophagy recept
neurodegeneration · failed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in