Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GABRD | expressed_in | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164] | Unknown | 2025 | 0 | |
| The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238] | Unknown | 2025 | 0 | |
| Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133] | Hyde VR, Zhou C, Fernandez JR, Chatterje | Cell reports | 2025 | 0 |
| Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433] | Carling GK, Fan L, Foxe NR, Norman K, Wo | Neuron | 2024 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623] | ["Jin Meihua", "Shiwaku Hiroki", "Tanaka | Nature communications | 2021 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
| Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple sys [PMID:9682846] | Unknown | Neuroscience letters | 1998 | 0 |
| Mutation in the alpha-synuclein gene identified in families with Parkinson's dis [PMID:9197268] | Unknown | Science (New York, N.Y.) | 1997 | 0 |
| Alpha-synuclein in Lewy bodies. [PMID:9278044] | Unknown | Nature | 1997 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PAG in their description or question text
Score: 0.760 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The cGAS-STING (cyclic GMP-AMP synthase - stimulator of interferon genes) pathway
Score: 0.752 · alzheimers · 2026-04-05
## Mechanistic Overview Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant
Score: 0.748 · alzheimers · 2026-04-05
## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and bloc
Score: 0.745 · neurodegeneration · 2026-05-10
AAV9-mediated overexpression of LAMP2A enhances chaperone-mediated autophagy to selectively degrade pathological alpha-s
Score: 0.718 · als · 2026-04-26
The hypothesis proposes that MMP-9 (matrix metalloproteinase-9), secreted via the senescence-associated secretory phenot
Score: 0.711 · neurodegeneration · 2026-04-02
## Mechanistic Overview Noradrenergic-Tau Propagation Blockade starts from the claim that modulating ADRA2A within the d
Score: 0.690 · neurodegeneration · 2026-04-21
## Mechanistic Overview Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex propagation at Bra
Score: 0.680 · neurodegeneration · 2026-04-25
Dying or stressed neurons release alpha-synuclein and DAMPs that activate microglia, which then generate superoxide thro
Score: 0.680 · neurodegeneration · 2026-04-24
Even if G2019S mainly elevates the kinase floor, that increase may still become pathogenic by pushing a thresholded down
Score: 0.640 · neurodegeneration · 2026-04-22
## **Molecular Mechanism and Rationale** The cyclin-dependent kinase 5 (CDK5) represents a critical regulatory node in
Score: 0.630 · neurodegeneration · 2026-04-22
## **Molecular Mechanism and Rationale** The autophagosome-lysosome fusion process represents a critical checkpoint in
Score: 0.626 · neurodegeneration · 2026-04-28
APOE ε4-driven microglial lipid handling should produce a measurable proximal phenotype before late disease pathology. T
Score: 0.620 · neurodegeneration · 2026-04-15
## Mechanistic Overview H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration start
Score: 0.620 · neurodegeneration · 2026-04-28
Neuronal activity induces CDK5-dependent tau phosphorylation and packaging into exosomes. Selective CDK5 inhibition prev