Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABRD is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, regulates. Associated with COAD, ESCC, GEFS+. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | GABRD |
| Full Name | GABA-A Receptor Delta Subunit |
| Chromosome | 1 |
| Protein Type | Channel |
| Function | The GABA-A receptor is a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system. |
| Subcellular Localization | , and trafficking of the receptor |
| UniProt ID | [O43513](https://www.uniprot.org/uniprotkb/O43513/entry) |
| Ensembl ID | ENSG00000187730 |
| GeneCards | GABRD |
| Human Protein Atlas | GABRD |
| Associated Diseases | COAD, ESCC, GEFS+, LGG, PMDD, cancer |
| Interactions | DEPDC1B |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GABRD["<b>GABRD</b>"]
COAD{"COAD"}
GABRD -->|"associated with"| COAD
sexual_behavior["sexual_behavior"]
GABRD -->|"associated with"| sexual_behavior
SCN["SCN"]
GABRD -->|"expressed in"| SCN
GEFS_{"GEFS+"}
GABRD -->|"associated with"| GEFS_
cancer{"cancer"}
GABRD -->|"associated with"| cancer
brain["brain"]
GABRD -->|"expressed in"| brain
PMDD{"PMDD"}
GABRD -->|"associated with"| PMDD
PAG["PAG"]
GABRD -->|"expressed in"| PAG
sperm["sperm"]
GABRD -->|"expressed in"| sperm
ESCC{"ESCC"}
GABRD -->|"associated with"| ESCC
LGG{"LGG"}
GABRD -->|"associated with"| LGG
neurodegeneration["neurodegeneration"]
GABRD -->|"implicated in"| neurodegeneration
DEPDC1B["DEPDC1B"]
DEPDC1B -->|"interacts with"| GABRD
TTR["TTR"]
TTR -->|"regulates"| GABRD
alcohol["alcohol"]
alcohol -->|"regulates"| GABRD
style GABRD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| COAD | associated_with | disease | 0.80 |
| sexual_behavior | associated_with | phenotype | 0.80 |
| SCN | expressed_in | brain_region | 0.80 |
| GEFS+ | associated_with | disease | 0.80 |
| cancer | associated_with | disease | 0.80 |
| brain | expressed_in | brain_region | 0.80 |
| PMDD | associated_with | disease | 0.80 |
| PAG | expressed_in | brain_region | 0.80 |
| sperm | expressed_in | cell_type | 0.80 |
| ESCC | associated_with | disease | 0.80 |
| LGG | associated_with | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||