gene

GABRD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
11Outgoing
3Incoming

Summary

GABRD is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, regulates. Associated with COAD, ESCC, GEFS+. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGABRD
Full NameGABA-A Receptor Delta Subunit
Chromosome1
Protein TypeChannel
FunctionThe GABA-A receptor is a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system.
Subcellular Localization, and trafficking of the receptor
UniProt ID[O43513](https://www.uniprot.org/uniprotkb/O43513/entry)
Ensembl IDENSG00000187730
GeneCardsGABRD
Human Protein AtlasGABRD
Associated DiseasesCOAD, ESCC, GEFS+, LGG, PMDD, cancer
InteractionsDEPDC1B
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

GABRD — GABA-A Receptor Delta Subunit

gene · 551 words

GABRA4 Gene

gene · 2602 words

GABRA6 Gene

gene · 2553 words

GABRA3 Gene

gene · 2410 words

GABRA5 Gene

gene · 2239 words

GABRB3 Gene

gene · 1921 words

Pathway Diagram

graph TD
    GABRD["<b>GABRD</b>"]
    COAD{"COAD"}
    GABRD -->|"associated with"| COAD
    sexual_behavior["sexual_behavior"]
    GABRD -->|"associated with"| sexual_behavior
    SCN["SCN"]
    GABRD -->|"expressed in"| SCN
    GEFS_{"GEFS+"}
    GABRD -->|"associated with"| GEFS_
    cancer{"cancer"}
    GABRD -->|"associated with"| cancer
    brain["brain"]
    GABRD -->|"expressed in"| brain
    PMDD{"PMDD"}
    GABRD -->|"associated with"| PMDD
    PAG["PAG"]
    GABRD -->|"expressed in"| PAG
    sperm["sperm"]
    GABRD -->|"expressed in"| sperm
    ESCC{"ESCC"}
    GABRD -->|"associated with"| ESCC
    LGG{"LGG"}
    GABRD -->|"associated with"| LGG
    neurodegeneration["neurodegeneration"]
    GABRD -->|"implicated in"| neurodegeneration
    DEPDC1B["DEPDC1B"]
    DEPDC1B -->|"interacts with"| GABRD
    TTR["TTR"]
    TTR -->|"regulates"| GABRD
    alcohol["alcohol"]
    alcohol -->|"regulates"| GABRD
    style GABRD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
COADassociated_withdisease0.80
sexual_behaviorassociated_withphenotype0.80
SCNexpressed_inbrain_region0.80
GEFS+associated_withdisease0.80
cancerassociated_withdisease0.80

Incoming (3)

SourceRelationTypeStr
DEPDC1Binteracts_withgene0.80
TTRregulatesgene0.80
alcoholregulatesdrug0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found