Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PANK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Pantothenate Kinase 4 - PANK4 - involved in coenzyme A biosynthesis and ciliary function, implicated in ciliopathies and potentially in neurodegenerative processes
| Gene Symbol | PANK4 |
| Full Name | Pantothenate Kinase 4 |
| Chromosome | 1p36.22 |
| Function | The enzyme catalyzes the first and rate-limiting step in the coenzyme A (CoA) biosynthetic pathway: the phosphorylation of vitamin B5 (pantothenate) to produce 4'-phosphopantothenate. |
| Primary Expression | various brain regions: |
| Subcellular Localization | PANK4 is primarily cytosolic but also localizes to specific cellular compartments including basal bodies of cilia. This |
| Amino Acids | 248 aa |
| Ensembl ID | ENSG00000155040 |
| GeneCards | PANK4 |
| Human Protein Atlas | PANK4 |
| Cerebral cortex | Moderate expression in pyramidal neurons |
| Hippocampus | Expression in CA regions and dentate gyrus |
| Cerebellum | Purkinje cells show detectable expression |
| Choroid plexus | High expression in this ciliated epithelial tissue |
| Associated Diseases | Alzheimer's Disease, Cognitive Trajectory, Pantothenate Kinase-Associated Neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
PANK4(["PANK4"])
Coenzyme_A("Coenzyme A")
Skeletal_Muscle_Substrate_Metabolism("Skeletal Muscle Substrate Metabo...")
AKT(["AKT"])
Pantothenate_Kinase_Associated_Neurodege["Pantothenate Kinase-Associated N..."]
Alzheimer_s_Disease["Alzheimer's Disease"]
Cognitive_Trajectory("Cognitive Trajectory")
neurodegeneration["neurodegeneration"]
PANK4 -->|"regulates"| Coenzyme_A
PANK4 -->|"associated with"| Skeletal_Muscle_Substrate_Metabolism
AKT -->|"regulates"| PANK4
PANK4 -->|"implicated in"| Pantothenate_Kinase_Associated_Neurodege
PANK4 -->|"associated with"| Alzheimer_s_Disease
PANK4 -->|"associated with"| Cognitive_Trajectory
PANK4 -->|"implicated in"| neurodegeneration
style PANK4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Coenzyme A | regulates | biological_process | 0.80 |
| Skeletal Muscle Substrate Metabolism | associated_with | biological_process | 0.80 |
| Pantothenate Kinase-Associated Neurodegeneration | implicated_in | disease | 0.70 |
| Cognitive Trajectory | associated_with | phenotype | 0.70 |
| Alzheimer's Disease | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||