| Gene Symbol | PANK4 |
| Full Name | Pantothenate Kinase 4 |
| Chromosome | 1p36.22 |
| Function | The enzyme catalyzes the first and rate-limiting step in the coenzyme A (CoA) biosynthetic pathway: the phosphorylation of vitamin B5 (pantothenate) to produce 4'-phosphopantothenate. |
| Primary Expression | various brain regions: |
| Subcellular Localization | PANK4 is primarily cytosolic but also localizes to specific cellular compartments including basal bodies of cilia. This |
| Amino Acids | 248 aa |
| Ensembl ID | ENSG00000155040 |
| GeneCards | PANK4 |
| Human Protein Atlas | PANK4 |
| Cerebral cortex | Moderate expression in pyramidal neurons |
| Hippocampus | Expression in CA regions and dentate gyrus |
| Cerebellum | Purkinje cells show detectable expression |
| Choroid plexus | High expression in this ciliated epithelial tissue |
| Associated Diseases | Alzheimer's Disease, Cognitive Trajectory, Pantothenate Kinase-Associated Neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |