gene

PANX2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PANX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PANX2 Gene

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🧬 Gene Info

Gene Symbol	PANX2
Full Name	Pannexin 2
Chromosome	22q13.1
Protein Type	Channel
Function	PANX2 encodes pannexin 2, the second member of the pannexin family of large-pore membrane channels.
UniProt ID	Q9NZU5
Ensembl ID	ENSG00000073150
GeneCards	PANX2
Human Protein Atlas	PANX2
Brain	Neurons (especially cortical and hippocampal), oligodendrocytes[@panx2_oligodendrocyte]
Spinal cord	Lower expression
Peripheral nervous system	Minimal expression
Developmentally regulated	Expression peaks during brain development
Cerebral cortex	High expression in pyramidal neurons[@panx2_cortex]
Hippocampus	Strong expression in CA1-CA3 regions and dentate gyrus[@panx2_hippocampus]
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PANX2 — AlphaFold Q9NZU5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PANX2 Gene

gene · 2531 words

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Pathway Diagram

graph TD
    PANX2["PANX2"]
    neurodegeneration["neurodegeneration"]
    PANX2 -->|"implicated_in"| neurodegeneration
    style PANX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PANX2 in their description or question text

No additional research found