gene 2,531 words KG: PANX2
Contents

PANX2 Gene

🧬 Gene Info
Gene SymbolPANX2
Full NamePannexin 2
Chromosome22q13.1
Protein TypeChannel
FunctionPANX2 encodes pannexin 2, the second member of the pannexin family of large-pore membrane channels.
UniProt IDQ9NZU5
Ensembl IDENSG00000073150
GeneCardsPANX2
Human Protein AtlasPANX2
BrainNeurons (especially cortical and hippocampal), oligodendrocytes[@panx2_oligodendrocyte]
Spinal cordLower expression
Peripheral nervous systemMinimal expression
Developmentally regulatedExpression peaks during brain development
Cerebral cortexHigh expression in pyramidal neurons[@panx2_cortex]
HippocampusStrong expression in CA1-CA3 regions and dentate gyrus[@panx2_hippocampus]
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · completed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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