protein

PDE1BPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE1BPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Pde1B Protein — Phosphodiesterase 1B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	PDE1BPROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	brain regions associated with learning and memory
Subcellular Localization	PDE activity creates cAMP microdomains ### Calcium Signaling Integration PDE1B
Molecular Weight	59 kDa
GeneCards	PDE1BPROTEIN
Human Protein Atlas	PDE1BPROTEIN
N-terminal regulatory domain	Contains two calcium/calmodulin-binding sites
Catalytic domain	Carboxy-terminal region with cAMP/cGMP hydrolysis activity
Calmodulin activation	Requires calcium-bound calmodulin for activation
Dimerization	Forms homodimers for proper function
cAMP levels	Controls intracellular cAMP concentration
cGMP levels	Also hydrolyzes cGMP, though preferentially cAMP
Spatial signaling	Localized PDE activity creates cAMP microdomains
Calcium influx	Activates PDE1B via calmodulin
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

pde1b-protein

protein · 558 words

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Pathway Diagram

graph TD
    PDE1BPROTEIN["PDE1BPROTEIN"]
    neurodegeneration["neurodegeneration"]
    PDE1BPROTEIN -->|"implicated_in"| neurodegeneration
    style PDE1BPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PDE1BPROTEIN in their description or question text

No additional research found