gene

PDE4A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PDE4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PDE4A — Phosphodiesterase 4A

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🧬 Gene Info

Gene Symbol	PDE4A
Full Name	Phosphodiesterase 4A
Function	PDE4A encodes a cAMP-specific phosphodiesterase belonging to the PDE4 family
UniProt ID	P27815
Ensembl ID	ENSG00000065989
GeneCards	PDE4A
Human Protein Atlas	PDE4A
cAMP → AMP	Catalyzes the breakdown of cAMP toAMP
cAMP-specific	Does not hydrolyze cGMP
Isoforms	Multiple splice variants (PDE4A1-11) with different N-termini
Phosphorylation	PKA phosphorylation can regulate activity
Protein interactions	Binds to various scaffolding proteins
Compartmentalization	Targeted to specific cellular compartments
High expression	Cerebral cortex, hippocampus, olfactory bulb, cerebellum
Moderate expression	Lung, immune cells, heart
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PDE4A — AlphaFold P27815 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PDE4A — Phosphodiesterase 4A

gene · 583 words

→

PDE4A Protein — cAMP-Specific Phosphodiesterase 4A

protein · 561 words

→

Pathway Diagram

graph TD
    PDE4A["PDE4A"]
    neurodegeneration["neurodegeneration"]
    PDE4A -->|"implicated_in"| neurodegeneration
    style PDE4A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PDE4A in their description or question text

No additional research found