Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about pdia1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | PDIA1 |
| Chromosome | 5q31.1 |
| Function | Oxidative folding: Formation of de novo disulfide bonds in nascent polypeptides entering the ER |
| Molecular Weight | 57 kDa |
| Amino Acids | 508 aa |
| UniProt ID | P07237 |
| NCBI Gene ID | 5036 |
| Ensembl ID | ENSG00000121594 |
| OMIM | 176870 |
| GeneCards | PDIA1 |
| Human Protein Atlas | PDIA1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
PDIA1["PDIA1"] -->|"interacts with"| Ras["Ras"]
PDIA1["PDIA1"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
RAS["RAS"] -->|"activates"| Tumor["Tumor"]
RAS["RAS"] -->|"associated with"| Cancer["Cancer"]
RAS["RAS"] -->|"activates"| Cancer["Cancer"]
RAS["RAS"] -->|"activates"| Apoptosis["Apoptosis"]
style PDIA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Ras fill:#006494,stroke:#333,color:#e0e0e0
style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
style RAS fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ras | interacts_with | protein | 0.60 |
| benchmark_ot_ad_answer_key:PDIA1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PDIA1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity