gene

RAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3672Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

15Experiments

0Debates

Summary

RAS is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ADH, ALS. Connected to 1154 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAS
Pathways	APOPTOSIS
GeneCards	RAS
Human Protein Atlas	RAS
Associated Diseases	AD, ADH, Aging, Als, Alzheimer
Known Drugs/Compounds	angiotensin receptor blockers, COENZYME Q10, KRAS inhibitors, Lonafarnib, MNNG, rapamycin
Interactions	ABCD3, ACAT1, ACOX1, ACTB, Actin, AD
KG Connections	2348 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAS["RAS"] -->|"regulates"| Ischemia["Ischemia"]
    RAS["RAS"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    RAS["RAS"] -->|"interacts"| Alzheimer["Alzheimer"]
    RAS["RAS"] -->|"interacts"| ALS["ALS"]
    RAS["RAS"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    RAS["RAS"] -->|"interacts"| Dementia["Dementia"]
    NF1["NF1"] -->|"regulates"| RAS["RAS"]
    CAMP["CAMP"] -->|"activates"| RAS["RAS"]
    MTOR["MTOR"] -->|"regulates"| RAS["RAS"]
    MYC["MYC"] -->|"regulates"| RAS["RAS"]
    style RAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1481)

Target	Relation	Type	Str
RAS	encodes	protein	0.00
Carcinoma	activates	disease	1.00
Tumor	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
Cancer	activates	disease	1.00
Tumor	inhibits	disease	1.00
Mapk	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
Cancer	associated_with	disease	1.00
Als	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Receptor Tyrosine Kinase	activates	pathway	1.00
AKT	activates	gene	1.00
Als	inhibits	disease	1.00
Apoptosis	activates	pathway	1.00
Mapk	associated_with	pathway	1.00
GENES	activates	gene	1.00
GENES	inhibits	gene	1.00
cellular functions	regulates	process	0.95
Als	associated_with	disease	0.95
Cancer	inhibits	disease	0.95
MAPK signaling pathway	upstream_of	pathway	0.95
MAPK Pathway	activates	pathway	0.95
cell proliferation	regulates	process	0.95
KRAS inhibitors	therapeutic_target	drug	0.95
Tumor	associated_with	disease	0.95
Mapk Pathway	activates	pathway	0.95
cancer	therapeutic_target	disease	0.95
colorectal cancer	associated_with	disease	0.95
Cancer	regulates	disease	0.95
Colorectal Cancer	activates	disease	0.95
gastric intestinal metaplasia	promotes	phenotype	0.90
Pancreatic Ductal Adenocarcinoma	risk_factor_for	disease	0.90
neural stem cells	regulates	cell_type	0.90
cell transformation	promotes	process	0.90
Carcinogenesis	involved_in	process	0.90
Erk Signaling	activates	pathway	0.90
EGF	activates	gene	0.90
Mtor	activates	pathway	0.90
AUTOPHAGY	activates	gene	0.90
CANCER	regulates	gene	0.90
Differentiation	activates	pathway	0.90
JAK	activates	gene	0.90
CANCER	inhibits	gene	0.90
acquired resistance	promotes	phenotype	0.88
Inflammation	activates	disease	0.85

Incoming (2191)

Source	Relation	Type	Str
RAS	encodes	gene	0.00
ERK	activates	gene	1.00
PI3K	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
KRAS	activates	gene	1.00
RAPAMYCIN	activates	drug	0.95
rapamycin	targets	drug	0.90
ATG	activates	gene	0.90
angiotensin receptor blockers	inhibits	drug	0.90
metabolic syndrome	causes	disease	0.90
EGFR	activates	gene	0.90
PI3K	targets	gene	0.90
MNNG	activates	drug	0.85
SPRED1	inhibits	protein	0.85
SHOC2	regulates	protein	0.80
AMPK	regulates	gene	0.80
BECN1	regulates	gene	0.80
NATURAL PRODUCTS	regulates	compound	0.80
Lonafarnib	inhibits	drug	0.80
NF1	regulates	gene	0.80
RAB7A	activates	gene	0.80
LAMP2	regulates	gene	0.80
CYTOKINES	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
ERK	therapeutic_target	gene	0.80
HIF	activates	gene	0.80
PI3K	inhibits	gene	0.80
KRAS	targets	gene	0.80
ERK	inhibits	gene	0.80
MAP1LC3B	activates	gene	0.75
FERROPTOSIS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
CREB	activates	gene	0.70
VEGF	therapeutic_target	gene	0.70
ROS	activates	gene	0.70
ERBB2	activates	gene	0.70
P53	inhibits	gene	0.70
STAT3	activates	gene	0.70
GABA	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
KRAS	associated_with	gene	0.70
BAX	inhibits	gene	0.70
GABA	activates	gene	0.70
MAP1LC3	activates	gene	0.70
PKC	activates	gene	0.70
PTEN	activates	gene	0.70
AMPK	activates	gene	0.70
NF-ΚB	activates	gene	0.70
PI3K	expressed_in	gene	0.70

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.865	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	alzheimers	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.827	alzheimers	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	alzheimers	Circuit-level neural dynamics in neurode
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.795	neurodegeneration	APOE4 structural biology and therapeutic
Closed-loop transcranial focused ultrasound to restore hippo	0.767	alzheimers	Circuit-level neural dynamics in neurode
Focused Ultrasound with Microbubble Contrast Agents for Anti	0.762	neurodegeneration	Blood-brain barrier antibody transport m
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.754	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.748	alzheimers	Circuit-level neural dynamics in neurode
Epigenetic Memory Erasure via TET2 Activation	0.741	neurodegeneration	Astrocyte reactivity subtypes in neurode
Focused Ultrasound with Microbubble Contrast Agents	0.684	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Astrocyte-Mediated Microglial Memory Erasure	0.677	-	Neuroinflammation and microglial priming
Closed-loop transcranial focused ultrasound targeting motor	0.633	als	-
APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma O	0.625	alzheimers	-
Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Traine	0.588	neuroinflammation	What specific astrocyte-derived factors
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.573	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting entorh	0.564	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.564	alzheimers	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.559	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.551	alzheimers	Circuit-level neural dynamics in neurode
NAD+ Precursor Supplementation to Reverse Poly(ADP-ribose) P	0.547	metabolomics	Metabolomic signatures of neurodegenerat
Closed-loop transcranial focused ultrasound with real-time g	0.546	alzheimers	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.542	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.000	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with gamma entra	0.000	alzheimers	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (15)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma pTau217 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
Dairy intake and dementia risk in Malmö Diet and Cancer cohort	clinical	Alzheimer's disease	0.950	0.00	Swedish community-based adults	proposed	N/A
GWAS of plasma pTau181 in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
GWAS of plasma GFAP in East Asian cohort	exploratory	Alzheimer's disease	0.950	0.00	human patients - East Asian co	proposed	N/A
KEEPS Continuation: Long-term effects of menopausal hormone therapy on	clinical	Alzheimer's disease	0.950	0.00	recently menopausal women with	proposed	N/A
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
GWAS of composite biomarker score	exploratory	Alzheimer's disease	0.900	0.00	human patients - East Asian co	proposed	N/A
RBG treatment in ApoE-/- atherosclerosis mouse model	validation	atherosclerosis	0.900	0.00	ApoE-/- mice	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int	in_vivo	Alzheimer's disease	0.765	0.55	APP/PS1 mice 8-11 months (n=10	abandoned	$125,000
tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal	in_vivo	Alzheimer's disease	0.744	0.48	hAPP-J20 mice (n=10/group x 3	abandoned	$110,000
s:** - Biochemical binding assays measuring PROTAC selectivity for APO	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216]	Banik SM, Pedram K, Wisnovsky S, Ahn G,	Nature	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188]	Cetindag AC, Schipke CG, Esselmann H, Kr	The journal of prevention of A	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204]	Sang Y, Cao Y, Li S, Quan Y, Wang S et a	Biomaterials	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0
Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pa [PMID:41930593]	Yoshida K, Saito N, Takahashi R, Ando S,	J Alzheimers Dis	2026	0
UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylati [PMID:41930933]	Ding SK	Immunol Invest	2026	0
Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disor [PMID:40145985]	Lozupone M, Leccisotti I, Mollica A, Ber	Neural regeneration research	2026	0
Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 [PMID:41912201]	Sabry HH, Kadhum BQ, Abdulmohsin GN, El-	Dermatology practical & concep	2026	0
Association of Periodontal Pathogens and Their Inflammatory Mediators With Alzhe [PMID:41890452]	Arriaga P, Vianna K, Montez C, Panariell	Cureus	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAS in their description or question text

RAS

Understanding Entity Pages

Summary

Wiki Pages (21)

Ras-MAPK Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

Pathway Diagram

Outgoing (1481)

Incoming (2191)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (15)

Related Papers (20)

Debates (0)

Related Research

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery

Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Epigenetic Memory Erasure via TET2 Activation

Focused Ultrasound with Microbubble Contrast Agents

Astrocyte-Mediated Microglial Memory Erasure

Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Trained Microglial NF-κB M

Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto

RAS

Understanding Entity Pages

Summary

Wiki Pages (21)

Ras-MAPK Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

CARASIL (Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)

RASGRF2

RASGRF1 Protein — Ras-GRF1

RASA3 — Ras GTPase-Activating Protein 3

RAB5C Gene — RAB5C, Member RAS Oncogene Family

RRAS1 Gene

RASA2 — RAS GTPase-Activating Protein 2

RAB29 — RAS-Related Protein Rab-29

RASA1 — RAS p120 GTPase Activating Protein

RASGRF2 (Ras-GRF2) Protein

RALB Protein - RAS-Related Protein Ral-B

RASGEF1A Protein

MRAS — Muscle RAS Oncogene

RALB Gene - RAS-Related Protein Ral-B

RASGEF1A

Pathway Diagram

Outgoing (1481)

Incoming (2191)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (15)

Related Papers (20)

Debates (0)

Related Research

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery

Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Epigenetic Memory Erasure via TET2 Activation

Focused Ultrasound with Microbubble Contrast Agents

Astrocyte-Mediated Microglial Memory Erasure

Astrocyte-Derived EV miR-146a-5p Mimics as Erasers of Trained Microglial NF-κB M

Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto