protein

Ras

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ras: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3650Connections

14Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	RAS
Pathways	APOPTOSIS
GeneCards	RAS
Human Protein Atlas	RAS
Associated Diseases	Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, Autism, Dementia
Interactions	neurofibromin, MTOR, AMPK, ABCA1, P2RY12, ABCG1
KG Connections	1328 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Ras["Ras"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ras["Ras"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ras["Ras"] -->|"associated"| Huntington["Huntington"]
    style Huntington fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ras["Ras"] -.->|"inhibits"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ras["Ras"] -->|"causes"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ras["Ras"] -.->|"inhibits"| Glioblastoma["Glioblastoma"]
    style Glioblastoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Ras["Ras"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurofibromin["neurofibromin"] -.->|"inhibits"| Ras["Ras"]
    style neurofibromin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MTOR["MTOR"] -.->|"inhibits"| Ras["Ras"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AMPK["AMPK"] -.->|"inhibits"| Ras["Ras"]
    style AMPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ABCA1["ABCA1"] -.->|"inhibits"| Ras["Ras"]
    style ABCA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    P2RY12["P2RY12"] -.->|"inhibits"| Ras["Ras"]
    style P2RY12 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Ras fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (1493)

Target	Relation	Type	Str
Atherosclerosis	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Alzheimer	inhibits	disease	0.60
Aging	causes	disease	0.60
Glioblastoma	inhibits	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Aging	regulates	disease	0.60
Cancer	protects_against	disease	0.60
Neuropathy	associated_with	disease	0.60
Senescence	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Als	phosphorylates	disease	0.60
Glioblastoma	activates	disease	0.60
Als	transports	disease	0.60
Multiple Sclerosis	regulates	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Fibrosis	activates	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Stroke	inhibits	disease	0.60
Aging	biomarker_for	disease	0.60
Pyroptosis	therapeutic_target	disease	0.60
Obesity	regulates	disease	0.60
Senescence	regulates	disease	0.60
Spinal Muscular Atrophy	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Als	degrades	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Stroke	therapeutic_target	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Fibrosis	therapeutic_target	disease	0.60
Aging	degrades	disease	0.60
Ischemia	degrades	disease	0.60
Aging	interacts_with	disease	0.60
Senescence	inhibits	disease	0.60
Epilepsy	activates	disease	0.60
Schizophrenia	activates	disease	0.60
Aging	expressed_in	disease	0.60
Als	contributes_to	disease	0.60
Neuropathy	expressed_in	disease	0.60
Ferroptosis	associated_with	disease	0.60
Ischemia	inhibits	disease	0.60
Anxiety	activates	disease	0.60
Obesity	inhibits	disease	0.60
Opioid	activates	disease	0.60
Addiction	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Schizophrenia	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60

Incoming (2157)

Source	Relation	Type	Str
neurofibromin	inhibits	protein	0.70
MTOR	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
ABCA1	inhibits	gene	0.60
P2RY12	inhibits	gene	0.60
ABCG1	inhibits	gene	0.60
ALS	inhibits	gene	0.60
MAO	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
ATP	inhibits	gene	0.60
ACTB	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
APOA1	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
SPP1	activates	gene	0.60
C1QA	activates	gene	0.60
GRN	activates	gene	0.60
RNA	activates	gene	0.60
CTSB	activates	gene	0.60
PPP3CB	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ATG10	activates	gene	0.60
HSPA8	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
DNA	associated_with	gene	0.60
TREHALOSE	activates	gene	0.60
MCOLN1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
ATG12	activates	gene	0.60
LGALS3	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
TREH	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CDK9	activates	gene	0.60
ADCY8	expressed_in	gene	0.60
PPAR	activates	gene	0.60
GLUT4	activates	gene	0.60
APOER2	inhibits	gene	0.60
REST	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
REELIN	inhibits	gene	0.60
CD2AP	inhibits	gene	0.60

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.595	neurodegeneration	APOE4 structural biology and therapeutic
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Epigenetic Memory Erasure via TET2 Activation	0.515	neurodegeneration	Astrocyte reactivity subtypes in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Astrocyte-Mediated Microglial Memory Erasure	0.462	-	Neuroinflammation and microglial priming

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the optimal BBB opening duration and spatial precision to maximize thera

neuropharmacology | 2026-04-11 | 0 hypotheses

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216]	Banik SM, Pedram K, Wisnovsky S, Ahn G,	Nature	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188]	Cetindag AC, Schipke CG, Esselmann H, Kr	The journal of prevention of A	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204]	Sang Y, Cao Y, Li S, Quan Y, Wang S et a	Biomaterials	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0
ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in [PMID:41651379]	Huang X, Sun YY, Qin YR, Chen H, Pan TT	J Control Release	2026	0
Albofungin vesicle nanobombs trigger lysosomal disruption for self-enhanced pyro [PMID:41679437]	Chen C, Tan S, Zhu X, Song Z, Xing Y et	J Control Release	2026	0
Covalent Bond Locking in Semiconducting Oligomers Boosts Ultrabright NIR-II Lumi [PMID:41757652]	Li X, Gan H, Zhang C, Gao Y, Zhang J et	Angew Chem Int Ed Engl	2026	0
Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pa [PMID:41930593]	Yoshida K, Saito N, Takahashi R, Ando S,	J Alzheimers Dis	2026	0
UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylati [PMID:41930933]	Ding SK	Immunol Invest	2026	0

Ras

Understanding Entity Pages

Wiki Pages (20)

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