Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PDP1 |
| Full Name | Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1 |
| Chromosome | 8q22.1 |
| Protein Type | Ser/Thr protein phosphatase |
| Primary Expression | Brain (high), heart, skeletal muscle, liver |
| Molecular Weight | 71 kDa |
| Amino Acids | 625 aa |
| Exons | 19 |
| UniProt ID | [Q9N2I8](https://www.uniprot.org/uniprot/Q9N2I8) |
| Ensembl ID | ENSG00000153540 |
| GeneCards | PDP1 |
| Human Protein Atlas | PDP1 |
| PDP1L1 | A testis-specific isoform with distinct regulatory properties |
| Calcium signaling | Activity-induced calcium influx can activate calmodulin-dependent pathways that influence PDP1 |
| Metabolic feedback | ATP/ADP ratios, NADH/NAD+ ratios, and pyruvate levels all affect PDC activity |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PDP1["PDP1"]
Als["Als"]
PDP1 -->|"expressed in"| Als
CLOCK["CLOCK"]
PDP1 -->|"expressed in"| CLOCK
neurodegeneration["neurodegeneration"]
PDP1 -->|"implicated in"| neurodegeneration
style PDP1 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PDP1 in their description or question text
No additional research found