Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLCG2 P522R Variant: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A gain-of-function missense variant (rs72824905) in the PLCG2 gene substituting proline for arginine at position 522. This protective variant increases PLCγ2 enzymatic activity by ~30%, enhancing microglial immune signaling and amyloid clearance. Carriers have a significantly reduced risk of Alzheimer's disease (OR ≈ 0.4), making it one of the strongest protective genetic factors.
Ontology: RCV000780944
No AI portrait yet
| Name | PLCG2 P522R |
| Related Diseases | Alzheimer disease |
| Related Pathways | gain-of-function |
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer disease | risk_factor_for | disease | 0.90 |
| gain-of-function | causes | mechanism | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning PLCG2 P522R Variant in their description or question text
No additional research found