Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLIN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive gene page for PLIN5 (Perilipin 5), also known as OXPAT, a lipid droplet-associated protein highly expressed in oxidative tissues including heart, skeletal muscle, and brain. PLIN5 regulates lipid storage, protects against lipotoxicity, and plays important roles in neurodegenerative diseases through lipid metabolism dysregulation, oxidative stress, and neuroinflammation.
| Gene Symbol | PLIN5 |
| Full Name | Perilipin 5 |
| Chromosome | 9q34.3 |
| Protein Family | Perilipin family (PLIN1-5) |
| Function | encodes a lipid droplet-associated protein that is highly expressed in oxidative tissues including the heart, skeletal muscle, and brown adipose tissue. |
| Primary Expression | oxidative tissues including the heart, skeletal muscle, and brown adipose tissue |
| Molecular Weight | 50 kDa |
| Amino Acids | 463 aa |
| UniProt ID | Q0VGN5 (PLIN5_HUMAN) |
| NCBI Gene ID | 440503 |
| Ensembl ID | ENSG00000165030 |
| OMIM | 613877 |
| GeneCards | PLIN5 |
| Human Protein Atlas | PLIN5 |
| Gene Name | Perilipin 5 (OXPAT) |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["PLIN5"]
N1["Rab8a"]
N1 -->|"binds to"| N0
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 protein| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Rab8a | binds_to | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||