protein

RAB8A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections
0Hypotheses
1Analyses
41Outgoing
19Incoming

Summary

Page for RAB8A — RAB8A Protein (Ras-Related Protein)

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🔬 Protein Info
Gene SymbolRAB8A
Full NameRAB8A, Member RAS Oncogene Family
AliasesRas-Related Protein
Chromosome19p13.2
FunctionRAB8A encodes a member of the Rab GTPase family, which are key regulators of intracellular vesicle trafficking
Molecular Weight24 kDa
PathwaysCholesterol
UniProt IDP61006
NCBI Gene ID51528
Ensembl IDENSG00000135569
OMIM608030
GeneCardsRAB8A
Human Protein AtlasRAB8A
StrategyDrug/Approach
ModulatorCID-1067700 (Rab inhibitor)
Associated Diseasesneurodegeneration
InteractionsNPC1, SMCR8, C9ORF72, SNAP23, STX4, ALS
KG Connections60 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RAB8A — AlphaFold P61006 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB8A — RAB8A, Member RAS Oncogene Family

gene · 614 words

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

mechanism · 4337 words

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

mechanism · 4302 words

LRRK2 Pathway in Parkinson's Disease

mechanism · 4238 words

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

event · 3615 words

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

event · 3615 words

Pathway Diagram

graph TD
    RAB8A["<b>RAB8A</b>"]
    Parkinson{"Parkinson"}
    RAB8A -->|"inhibits"| Parkinson
    Ms{"Ms"}
    RAB8A -->|"inhibits"| Ms
    Als{"Als"}
    RAB8A -->|"therapeutic target"| Als
    RAB8A -->|"interacts with"| Ms
    NPC1["NPC1"]
    RAB8A -->|"inhibits"| NPC1
    Cholesterol(["Cholesterol"])
    RAB8A -->|"regulates"| Cholesterol
    CANX["CANX"]
    RAB8A -->|"therapeutic target"| CANX
    HSPA5["HSPA5"]
    RAB8A -->|"therapeutic target"| HSPA5
    neurodegeneration["neurodegeneration"]
    RAB8A -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"inhibits"| RAB8A
    LRRK2["LRRK2"]
    LRRK2 -->|"regulates"| RAB8A
    RAB7A["RAB7A"]
    RAB7A -->|"therapeutic target"| RAB8A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| RAB8A
    IGF2R["IGF2R"]
    IGF2R -->|"therapeutic target"| RAB8A
    CAPZB["CAPZB"]
    CAPZB -->|"therapeutic target"| RAB8A
    RAB5A["RAB5A"]
    RAB5A -->|"therapeutic target"| RAB8A
    HSPA1A["HSPA1A"]
    HSPA1A -->|"therapeutic target"| RAB8A
    style RAB8A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

TargetRelationTypeStr
Autophagyregulatesprocess0.85
autophagy pathwayparticipates_inpathway0.70
Parkinsoninhibitsdisease0.65
Msinhibitsdisease0.65
Alstherapeutic_targetdisease0.65

Incoming (20)

SourceRelationTypeStr
LRRK2phosphorylatesprotein0.90
C9Orf72-Smcr8interacts_withprotein0.90
C9orf72-SMCR8 Complexmodulatesprotein0.80
LRRK2regulatesgene0.60
RAB7Atherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found