gene

PLXNA1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PLXNA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PLXNA1 Gene

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🧬 Gene Info

Gene Symbol	PLXNA1
Chromosome	3q21.3
Protein Type	Gene
Function	encodes a transmembrane receptor for semaphorins, playing critical roles in axonal guidance, neural circuit formation, and synaptic plasticity throughout development and in the adult nervous system.
Molecular Weight	210 kDa
Amino Acids	018 aa
Exons	31
Pathways	PI3K, MAPK
GeneCards	PLXNA1
Human Protein Atlas	PLXNA1
Cerebellum	Purkinje cells
Spinal cord	Motor neurons (alpha and gamma motor neurons)
Dorsal root ganglia	Sensory neurons
Developing brain	Particularly during embryogenesis and early postnatal periods
Plexin homology (PH) domain	Contains GTPase-activating protein (GAP) activity[@plexin2018]
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLXNA1 Gene

gene · 1092 words

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Pathway Diagram

graph TD
    PLXNA1["PLXNA1"]
    neurodegeneration["neurodegeneration"]
    PLXNA1 -->|"implicated_in"| neurodegeneration
    style PLXNA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PLXNA1 in their description or question text

No additional research found