gene

PLXNA2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PLXNA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PLXNA2 Gene

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🧬 Gene Info

Gene Symbol	PLXNA2
Chromosome	1q23.3
Protein Type	Gene
Function	encodes a member of the plexin family of transmembrane receptors for semaphorins, playing critical roles in neural development, circuit formation, and synaptic plasticity.
Molecular Weight	220 kDa
Amino Acids	034 aa
Exons	33
GeneCards	PLXNA2
Human Protein Atlas	PLXNA2
Cerebellum	Purkinje cells and granule cells
Olfactory bulb	mitral and tufted cells
Thalamus	relay neurons
Substantia nigra	dopaminergic neurons
Axonal repulsion	SEMA3A binding to PLXNA2 triggers growth cone collapse through RhoA/ROCK-dependent cytoskeletal remodeling[@plexin2021]
Synaptic scaling	PLXNA2 modulates AMPA receptor trafficking via Rap GAP activity[@plexin2022]
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLXNA2 Gene

gene · 1231 words

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Pathway Diagram

graph TD
    PLXNA2["PLXNA2"]
    neurodegeneration["neurodegeneration"]
    PLXNA2 -->|"implicated_in"| neurodegeneration
    style PLXNA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PLXNA2 in their description or question text

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