Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PM20D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PM20D1 |
| Full Name | Peptidase M20 Domain Containing 1 |
| Protein Family | M20 peptidase family |
| Function | is a mitochondrial peptidase that has emerged as a significant player in Parkinson's disease (PD) pathogenesis. |
| Subcellular Localization | Mitochondria, Cytoplasm |
| Molecular Weight | 58 kDa |
| Amino Acids | 400 aa |
| UniProt ID | Q9NWU1 |
| GeneCards | PM20D1 |
| Human Protein Atlas | PM20D1 |
| Mitochondrial Targeting Sequence | An N-terminal targeting sequence directs PM20D1 to mitochondria. This sequence is cleaved upon mitochondrial import, yielding the mature protein. |
| Dimerization Interface | PM20D1 likely functions as a homodimer, with dimerization mediated by residues in the C-terminal region. Dimer formation may be required for enzymatic activity. |
| Protein Interaction Domains | Regions outside the catalytic domain likely mediate interactions with other proteins, including components of the mitochondrial protein quality control machinery. |
| Peptidase Activity | As a member of the M20 peptidase family, PM20D1 may hydrolyze peptide bonds. Substrates could include mitochondrial peptides generated during protein turnover or imported from the cytosol. |
| Amino Acid Metabolism | PM20D1 may participate in amino acid catabolism or synthesis, particularly in mitochondria where it could process intermediates of the urea cycle or related pathways. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PM20D1["PM20D1"]
neurodegeneration["neurodegeneration"]
PM20D1 -->|"implicated_in"| neurodegeneration
style PM20D1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PM20D1 in their description or question text
No additional research found