PPP3CC

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP3CC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Protein Phosphatase 3 Catalytic Subunit Gamma - brain-specific calcineurin isoform involved in synaptic plasticity and neurodegeneration

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flowchart TD
    N0["PPP3CC"]
    N1["ITPKC"]
    N0 -->|"binds"| N1
    N2["Sustained Attention"]
    N0 -->|"associated with"| N2
    N3["Executive Functioning"]
    N0 -->|"associated with"| N3
    N0 -->|"stabilizes"| N1
    N4["GADD45B"]
    N4 -->|"activates"| N0
    N5["Psoriatic Arthritis"]
    N0 -->|"associated with"| N5
    N6["Schizophrenia"]
    N0 -->|"associated with"| N6
    N7["IP3"]
    N0 -->|"regulates"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N4 gene
    class N5 disease
    class N6 disease