disease

Schizophrenia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Schizophrenia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1330Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Schizophrenia is a disease characterized by neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 360 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	TGM2, HTR2A, DISC1, FKBP5, NRG1, DAO, BMAL1, GRM4
Therapeutic Agents	MTOR Inhibitors
KG Connections	720 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Schizophrenia["Schizophrenia"] -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    Schizophrenia["Schizophrenia"] -.->|"inhibits"| Complement["Complement"]
    Schizophrenia["Schizophrenia"] -->|"therapeutic target"| Mtor["Mtor"]
    Schizophrenia["Schizophrenia"] -->|"therapeutic target"| Autophagy["Autophagy"]
    Schizophrenia["Schizophrenia"] -->|"activates"| Synaptic_Plasticity_1["Synaptic Plasticity"]
    Schizophrenia["Schizophrenia"] -->|"activates"| Neurogenesis["Neurogenesis"]
    PLA2G4A["PLA2G4A"] -->|"risk factor for"| Schizophrenia["Schizophrenia"]
    Lipid_Homeostasis["Lipid Homeostasis"] -->|"involved in"| Schizophrenia["Schizophrenia"]
    PLA2_Superfamily["PLA2 Superfamily"] -->|"involved in"| Schizophrenia["Schizophrenia"]
    PLA2G6["PLA2G6"] -->|"risk factor for"| Schizophrenia["Schizophrenia"]
    style Schizophrenia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (350)

Target	Relation	Type	Str
Als	associated_with	disease	0.85
Synaptic Plasticity	implicated_in	pathway	0.80
Depression	associated_with	disease	0.75
Oxidative Stress	therapeutic_target	pathway	0.70
Alzheimer	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Synaptic Plasticity	regulates	pathway	0.60
Complement	inhibits	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Neurogenesis	activates	pathway	0.60
Circadian Rhythm	associated_with	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
Oxidative Stress	inhibits	pathway	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Neurogenesis	contributes_to	pathway	0.60
Telomere	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Blood-Brain Barrier	implicated_in	pathway	0.60
Immune Response	activates	pathway	0.60
Bipolar	associated_with	disease	0.55
Epilepsy	associated_with	disease	0.55
Autism	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Aging	associated_with	disease	0.55
Migraine	associated_with	disease	0.55
Huntington	associated_with	disease	0.55
Ischemia	associated_with	disease	0.55
Tumor	associated_with	disease	0.55
Parkinson	associated_with	disease	0.55
Dementia	associated_with	disease	0.55
Synaptic Plasticity	associated_with	pathway	0.55
Myelination	regulates	pathway	0.55
Neurogenesis	regulates	pathway	0.55
Toll-Like Receptor	regulates	pathway	0.55
Dendritic Spine	regulates	pathway	0.55
Dopamine Signaling	regulates	pathway	0.55
Mtor	inhibits	pathway	0.55
Autophagy	associated_with	pathway	0.55
Myelination	activates	pathway	0.55
Cerebrovascular	causes	pathway	0.55
Senescence	causes	pathway	0.55
Ischemia	inhibits	disease	0.55

Incoming (980)

Source	Relation	Type	Str
PLA2G4A	risk_factor_for	gene	0.95
TNFSF	implicated_in	pathway	0.95
Metabolism And Inflammation-Related Genes	involved_in	pathway	0.95
TNFSF	upregulates	pathway	0.95
C4A	risk_factor_for	gene	0.93
Dopamine Signaling	associated_with	pathway	0.90
RLN1	associated_with	protein	0.90
Dopamine	associated_with	entity	0.90
Postsynaptic Interactomes	associated_with	pathway	0.90
OXIDATIVE STRESS	therapeutic_target	gene	0.85
DEPRESSION	associated_with	gene	0.85
Lipid Homeostasis	involved_in	process	0.85
LCPUFA Deficiency	risk_factor_for	phenotype	0.85
Haloperidol	risk_factor_for	drug	0.85
mTOR-Dependent Autophagy Dysfunction	contributes_to	mechanism	0.85
Complement Activation	contributes_to	process	0.85
RLN	associated_with	protein	0.85
Pla2 Superfamily	involved_in	protein	0.85
Cpla2	involved_in	protein	0.85
HDC	biomarker_for	gene	0.85
NCKAP1L	biomarker_for	gene	0.85
FUCA1	biomarker_for	gene	0.85
CD40LG	biomarker_for	gene	0.85
CX3CR1	biomarker_for	gene	0.85
SNAP25	biomarker_for	gene	0.85
Mtnr1B	therapeutic_target	protein	0.85
Tnf Receptor Inhibition	therapeutic_target	mechanism	0.85
PLA2 Superfamily	involved_in	pathway	0.80
Microbiota	associated_with	process	0.80
MTOR Inhibitors	treats	drug	0.80
NPAS3	associated_with	gene	0.80
Lipid Homeostasis	contributes_to	process	0.80
Serotonin	associated_with	compound	0.80
PLA2G4F	risk_factor_for	gene	0.80
PLA2G12F	risk_factor_for	gene	0.80
Lcpufa Deficiency	causes	phenotype	0.80
Cpla2	biomarker_for	biomarker	0.80
cytosolic phospholipase A2	biomarker_for	protein	0.80
PLA2G6	risk_factor_for	gene	0.78
PLA2G3	risk_factor_for	gene	0.78
BDNF	associated_with	gene	0.75
MET	associated_with	gene	0.75
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.75
INFLAMMATION	associated_with	gene	0.75
BDNF	therapeutic_target	gene	0.75
ANXIETY	associated_with	gene	0.75
DEPRESSION	activates	gene	0.75
AGING	associated_with	gene	0.75
OXIDATIVE STRESS	associated_with	gene	0.75
IL-6	associated_with	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Schizophrenia

Understanding Entity Pages

Summary

Wiki Pages (21)

L23 Interneurons Schizophrenia

primary-progressive-aphasia

GRIA3 Gene

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

CNTN5 — Contactin 5

CNTN4 — Contactin 4

Sulforaphane and Nrf2 Activation for Neuroprotection

substantia-nigra

dimethyl-fumarate-nrf2-ad-nct06850597

CNTN3 — Contactin 3

NPAS3 Gene

PEN2 Gene

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Beta-Secretase (BACE1) Protein

Multiple Sclerosis (MS)

Metabolomic Alterations in PSP