gene

PRDX4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PRDX4 — Peroxiredoxin 4

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🧬 Gene Info

Gene Symbol	PRDX4
Full Name	Peroxiredoxin 4
Chromosome	19p13.13
Protein Type	Enzyme
Function	PRDX4 functions as a thiol-dependent peroxidase using a conserved cysteine residue (Cys^157) at its active site to reduce peroxides[@park2000].
Primary Expression	Cerebral cortex, Hippocampus, Liver, Kidney
Subcellular Localization	positions PRDX4 as a critical regulator of ER redox homeostasis and extracellular oxidative stress
Pathways	NF-κB
UniProt ID	Q9BZL1
NCBI Gene ID	10599
Ensembl ID	ENSG00000179673
OMIM	607723
GeneCards	PRDX4
Human Protein Atlas	PRDX4
ER Redox Homeostasis	Maintains the ER lumen in a reduced state necessary for proper protein folding
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRDX4 — AlphaFold Q9BZL1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRDX4 — Peroxiredoxin 4

gene · 562 words

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Pathway Diagram

graph TD
    PRDX4["PRDX4"]
    neurodegeneration["neurodegeneration"]
    PRDX4 -->|"implicated_in"| neurodegeneration
    style PRDX4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PRDX4 in their description or question text

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