gene

PRKAR1A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PRKAR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PRKAR1A gene encoding the type 1A regulatory subunit of cAMP-dependent protein kinase, with roles in neuronal signaling, CREB-mediated transcription, and neurodegeneration

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🧬 Gene Info

Gene Symbol	PRKAR1A
Full Name	Protein Kinase A Regulatory Subunit 1 Alpha
Function	encodes the type 1A (RIα) regulatory subunit of cAMP-dependent protein kinase (PKA), also known as protein kinase A[@walsh1966]
Ensembl ID	ENSG00000163644
GeneCards	PRKAR1A
Human Protein Atlas	PRKAR1A
RIα (PRKAR1A product)	Ubiquitously expressed, first discovered
RIβ	Enriched in brain
RIIα	Widely expressed
RIIβ	Enriched in brain and endocrine tissues
N-terminal dimerization domain (D/D)	Mediates R-subunit homodimerization
Linker region	Contains substrate docking and inhibition sequences
C-terminal region	Contributes to structural stability
Catalytic core	Kinase domain with activation loop phosphorylation site (Thr197 in Cα)
Myristylation site	N-terminal Gly that anchors C subunits to membranes
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKAR1A - Protein Kinase A Regulatory Subunit 1 Alpha

gene · 1584 words

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Pathway Diagram

graph TD
    PRKAR1A["PRKAR1A"]
    neurodegeneration["neurodegeneration"]
    PRKAR1A -->|"implicated_in"| neurodegeneration
    style PRKAR1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PRKAR1A in their description or question text

No additional research found