Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRKG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PRKG1 |
| Full Name | Protein Kinase cGMP-Dependent 1 |
| Chromosome | 10q21.3 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a key effector of the nitric oxide (NO)-cGMP signaling pathway and plays important roles in neuronal function, synaptic plasticity, and cardiovascular regulation. |
| NCBI Gene ID | 5590 |
| GeneCards | PRKG1 |
| Human Protein Atlas | PRKG1 |
| PKG1α | Higher affinity for cGMP, predominant in cerebellum |
| PKG1β | Lower cGMP affinity, more widely expressed [@pkg] |
| Synaptic plasticity | PKG is required for long-term potentiation (LTP) and long-term depression (LTD) [@pkga] |
| Gene expression | Phosphorylates transcription factors including CREB |
| Ion channel function | Modulates NMDA receptor activity and calcium channels |
| Dendritic spine morphology | Regulates spine formation and maintenance [@pkg2003] |
| Axon guidance | Controls growth cone dynamics |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
PRKG1["PRKG1"]
neurodegeneration["neurodegeneration"]
PRKG1 -->|"implicated_in"| neurodegeneration
style PRKG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PRKG1 in their description or question text
No additional research found