Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PROSAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information on SHANK2, a synaptic scaffold protein linked to Alzheimer's disease, Parkinson's disease, and autism spectrum disorders.
| Gene Symbol | PROSAP1 |
| Full Name | Proline-Rich Synaptic-Associated Protein 1 |
| Chromosome | 11q13.2 |
| Protein Type | Scaffold Protein |
| Function | is a critical postsynaptic scaffold protein that orchestrates the organization of the postsynaptic density (PSD) in excitatory synapses. |
| Primary Expression | heart, skeletal muscle, and testis |
| Molecular Weight | ~225 kDa |
| Amino Acids | 070 aa |
| Exons | 24 |
| UniProt ID | Q9UHB6 |
| NCBI Gene ID | 22989 |
| Ensembl ID | ENSG00000046192 |
| OMIM | 606344 |
| GeneCards | PROSAP1 |
| Human Protein Atlas | PROSAP1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PROSAP1["PROSAP1"]
neurodegeneration["neurodegeneration"]
PROSAP1 -->|"implicated_in"| neurodegeneration
style PROSAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||