Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PROTEOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Mortality Risk | associated_with | phenotype | 0.88 |
| NEUROTRAUMA | associated_with | disease | 0.64 |
| ALZHEIMERS_DISEASE | associated_with | disease | 0.56 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Genome-Wide Genetic Variation | modulates | process | 0.92 |
| CSF | contains | brain_region | 0.64 |
| AD | regulates | disease | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Exosomal SNCA Propagation from Lysosome-Compromised Neurons | 0.777 | neurodegeneration | - |
| C1q Binding to Specific Synaptic Proteomes via Neurexin/Neur | 0.522 | synaptic-biology | What determines the selectivity of compl |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in [PMID:37235660] | Chung HY, Wickel J, Hahn N, Mein N, Schw | Science advances | 2023 | 0 |
| Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and th [PMID:33628204] | Kovács, Vadászi, Bulyáki, | Frontiers in immunology | 2021 | 0 |
| Complement System in Neural Synapse Elimination in Development and Disease. [PMID:28826529] | ["Presumey J", "Bialas A", "Carroll M"] | Advances in immunology | 2017 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PROTEOME in their description or question text
No additional research found