SciDEX — AD

disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

240Connections

30Hypotheses

30Analyses

9Outgoing

50Incoming

Summary

AD is a disease characterized by neurodegeneration research. Key relationships include: implicated in, associated with, causes. Associated with DEMENTIA, T2D, T2DM. Connected to 236 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	TAU, SNCA, BETA_AMYLOID, PHOSPHORYLATED_TAU, SOD1, PARK7, MAP1B, MAP2
Therapeutic Agents	HTL9936
KG Connections	239 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AD["AD"] -->|"causes"| neurodegeneration["neurodegeneration"]
    AD["AD"] -->|"causes"| memory_loss["memory_loss"]
    AD["AD"] -->|"associated"| TAU["TAU"]
    AD["AD"] -->|"causes"| IMMUNE_TOL["IMMUNE_TOL"]
    AD["AD"] -->|"causes"| DEMENTIA["DEMENTIA"]
    AD["AD"] -.->|"inhibits"| cholinergic_transmission["cholinergic_transmission"]
    TAU_1["TAU"] -->|"associated"| AD["AD"]
    BETA_AMYLOID["BETA_AMYLOID"] -->|"causes"| AD["AD"]
    PHOSPHORYLATED_TAU["PHOSPHORYLATED_TAU"] -->|"causes"| AD["AD"]
    SOD1["SOD1"] -->|"associated"| AD["AD"]
    style AD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
neurodegeneration	causes	phenotype	0.87
memory_loss	causes	phenotype	0.72
TAU	associated_with	protein	0.72
IMMUNE_TOL	causes	phenotype	0.72
DEMENTIA	causes	disease	0.72
cholinergic_transmission	inhibits	pathway	0.64
PROTEOME	regulates	pathway	0.64
CHOLINERGIC_TRANSMISSION	associated_with	pathway	0.64
GLYCOLYTIC_PATHWAY	associated_with	pathway	0.56

Incoming (231)

Source	Relation	Type	Str
TAU	implicated_in	entity	0.90
TAU	associated_with	protein	0.87
APOE	associated_with	entity	0.85
MIR-146A	associated_with	mirna	0.80
BETA_AMYLOID	causes	protein	0.72
PHOSPHORYLATED_TAU	causes	protein	0.72
SOD1	associated_with	gene	0.72
TAU	causes	protein	0.64
AGE	associated_with	phenotype	0.64
MICROGLIA	associated_with	cell_type	0.64
T2D	associated_with	disease	0.64
SNCA	associated_with	gene	0.64
NEUROINFLAMMATION	contributes_to	phenotype	0.64
T2DM	associated_with	disease	0.64
HTL9936	treats	drug	0.64
PARK7	associated_with	gene	0.64
glycolytic_pathway	associated_with	pathway	0.56
NEUROTROPHINS	treats	protein	0.56
INFLAMMATION	contributes_to	pathway	0.56
ER_STRESS	contributes_to	pathway	0.56
AUTOPHAGY	contributes_to	pathway	0.56
MITOCHONDRIAL_DYSFUNCTION	contributes_to	phenotype	0.56
GLYCOLYTIC_PATHWAY	associated_with	pathway	0.56
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
GLUT4	implicated_in	gene	0.50
PPAR	implicated_in	gene	0.50
RAB7A	implicated_in	gene	0.50
LRP2	implicated_in	gene	0.50
ACTB	implicated_in	gene	0.50
CTSD	implicated_in	gene	0.50
ATG	implicated_in	gene	0.50
EGFR	implicated_in	gene	0.50
SREBF1	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
MTORC1	implicated_in	gene	0.50
PPARG	implicated_in	gene	0.50
RPS6KB1	implicated_in	gene	0.50
PPARA	implicated_in	gene	0.50
LAMP1	implicated_in	gene	0.50
RUBCN	implicated_in	gene	0.50
MTOR	implicated_in	gene	0.50
RAS	implicated_in	gene	0.50
RPS6	implicated_in	gene	0.50
PIK3C3	implicated_in	gene	0.50
ATP	implicated_in	gene	0.50
SQSTM1	implicated_in	gene	0.50
CAT	implicated_in	gene	0.50
ROS	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.703	neurodegeneration	Senolytic therapy for age-related neurod
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across

Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Circadian Glymphatic Entrainment via Targeted Orexin Recepto	0.623	neurodegeneration	Perivascular spaces and glymphatic clear
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.614	neurodegeneration	What is the molecular mechanism by which
Senescence-Activated NAD+ Depletion Rescue	0.604	neurodegeneration	Senolytic therapy for age-related neurod
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.596	neuroinflammation	What molecular mechanisms determine whet
Selective APOE4 Degradation via Proteolysis Targeting Chimer	0.595	neurodegeneration	APOE4 structural biology and therapeutic
Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove	0.592	neurodegeneration	Epigenetic reprogramming in aging neuron
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran
GDNF Gradient Establishment by Schwann Cells Enables Motor R	0.585	neurodegeneration	What molecular mechanisms enable functio
Circadian-Synchronized Proteostasis Enhancement	0.584	neurodegeneration	Digital biomarkers and AI-driven early d
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.559	neurodegeneration	How does PIKFYVE inhibition activate unc
Adenosine-Astrocyte Metabolic Reset	0.557	neurodegeneration	Sleep disruption as cause and consequenc
Senescent Cell ASM-Complement Cascade Intervention	0.552	neurodegeneration	Lipid raft composition changes in synapt
Circadian Clock-Autophagy Synchronization	0.547	neurodegeneration	Sleep disruption as cause and consequenc
Circadian Glymphatic Rescue Therapy (Melatonin-focused)	0.546	neurodegeneration	Sleep disruption as cause and consequenc
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Senescence-Induced Lipid Peroxidation Spreading	0.533	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868]	Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X	Pharmacol Rep	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662]	Dashti HS, Daghlas I, Lane JM, Huang Y,	Nat Commun	2021	1
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813]	Sun Y, Tisdale RK, Kilduff TS	Front Neurol Neurosci	2021	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021]	Xie M, Feng L, Li R, Li M, Shen L, Zhang	CNS neuroscience & therapeutic	2026	0
Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756]	Perez-Toledo M, Aksu-Istil K, Marcial-Ju	mBio	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448]	Taxiarchis A, Pruner I	Current opinion in hematology	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026	0
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361]	Han SC, Han J, Min YK, Han JW, Jeong HJ	Am J Sports Med	2026	0
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026	0
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967]	Huang X, Francis I, Gu Y, Saha SC	Respir Physiol Neurobiol	2026	0
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313]	Samante FI, Galangue CG, Avelino DC, Bel	Pharmacol Rep	2026	0

AD

Understanding Entity Pages

Summary

Wiki Pages (21)

AT(N) Biomarker Classification for Alzheimer's Disease

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Pathway Diagram

Outgoing (9)

Incoming (231)

Targeting Hypotheses (30)

Mentioning Analyses (30)

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Are interneuron oscillation deficits compensatory responses or primary pathologi

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How does pericyte senescence mechanistically promote glioma cell growth and inva

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How does APOE4's beneficial immune function reconcile with its established role

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

What signals trigger microglia to specifically recognize and phagocytose LC axon

How do P/Q channel deficits paradoxically increase thalamic excitability despite

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

Related Papers (20)