gene

PRPF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRPF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PRPF3 encodes a core component of the U4/U6.U5 tri-snRNP complex essential for pre-mRNA splicing. Mutations cause retinitis pigmentosa, and dysfunction is implicated in neurodegeneration through defective RNA processing.

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🧬 Gene Info

Gene Symbol	PRPF3
Full Name	Pre-mRNA Processing Factor 3
Chromosome	1q21.1
Function	is a critical step in eukaryotic gene expression that removes non-coding introns and joins coding exons to produce mature messenger RNA.
Molecular Weight	75 kDa
Amino Acids	683 aa
Exons	16
UniProt ID	[O43371](https://www.uniprot.org/uniprot/O43371)
Ensembl ID	ENSG00000148408
GeneCards	PRPF3
Human Protein Atlas	PRPF3
Core tri-snRNP	PRPF3 is one of seven "SNRNP core proteins" that define the identity of the tri-snRNP
U4/U6 snRNA binding	The protein contacts both U4 and U6 snRNAs, stabilizing their base-paired structure
Prp19 complex interaction	PRPF3 interacts with the Prp19 complex during spliceosome activation
Catalytic center proximity	During activation, PRPF3 positions near the catalytic center of the spliceosome
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRPF3["PRPF3"]
    neurodegeneration["neurodegeneration"]
    PRPF3 -->|"implicated_in"| neurodegeneration
    style PRPF3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PRPF3 in their description or question text

No additional research found