| Gene Symbol | PRPF3 |
| Full Name | Pre-mRNA Processing Factor 3 |
| Chromosome | 1q21.1 |
| Function | is a critical step in eukaryotic gene expression that removes non-coding introns and joins coding exons to produce mature messenger RNA. |
| Molecular Weight | 75 kDa |
| Amino Acids | 683 aa |
| Exons | 16 |
| UniProt ID | [O43371](https://www.uniprot.org/uniprot/O43371) |
| Ensembl ID | ENSG00000148408 |
| GeneCards | PRPF3 |
| Human Protein Atlas | PRPF3 |
| Core tri-snRNP | PRPF3 is one of seven "SNRNP core proteins" that define the identity of the tri-snRNP |
| U4/U6 snRNA binding | The protein contacts both U4 and U6 snRNAs, stabilizing their base-paired structure |
| Prp19 complex interaction | PRPF3 interacts with the Prp19 complex during spliceosome activation |
| Catalytic center proximity | During activation, PRPF3 positions near the catalytic center of the spliceosome |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |