gene

PSENEN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSENEN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for PSENEN Gene - Presenilin Enhancer

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🧬 Gene Info

Gene Symbol	PSENEN
Aliases	Page for PSENEN Gene
Chromosome	19q13.12
Protein Type	Protease
Function	Presenilin endoproteolysis — PEN-2 is required for the autocatalytic cleavage of presenilin to generate the active N-terminal and C-terminal fragments
Primary Expression	Brain (cerebral cortex, hippocampus), Heart, Liver, Lung, Kidney
Amino Acids	101 aa
UniProt ID	Q9BXG4
NCBI Gene ID	55851
Ensembl ID	ENSG00000105254
OMIM	607632
GeneCards	PSENEN
Human Protein Atlas	PSENEN
Associated Diseases	Alzheimer's Disease, Familial Alzheimer's Disease
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PSENEN — AlphaFold Q9BXG4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PSENEN Gene - Presenilin Enhancer

gene · 973 words

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Pathway Diagram

graph TD
    PSENEN["PSENEN"]
    neurodegeneration["neurodegeneration"]
    PSENEN -->|"implicated_in"| neurodegeneration
    style PSENEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSENEN in their description or question text

No additional research found