gene 973 words KG: PSENEN 2026-03-21
kind:genesection:genesstate:published
Contents

PSENEN Gene - Presenilin Enhancer

🧬 Gene Info
Gene SymbolPSENEN
AliasesPage for PSENEN Gene
Chromosome19q13.12
Protein TypeProtease
FunctionPresenilin endoproteolysis — PEN-2 is required for the autocatalytic cleavage of presenilin to generate the active N-terminal and C-terminal fragments
Primary ExpressionBrain (cerebral cortex, hippocampus), Heart, Liver, Lung, Kidney
Amino Acids101 aa
UniProt IDQ9BXG4
NCBI Gene ID55851
Ensembl IDENSG00000105254
OMIM607632
GeneCardsPSENEN
Human Protein AtlasPSENEN
Symbol [@gammasecretase2009] PSENEN [@pen2010] [@presenilin2013] [@psenen2007] Full NameGamma-Secretase Subunit PEN-2
Associated DiseasesAlzheimer's Disease, Familial Alzheimer's Disease
KG Connections2 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

PSENEN provides_data_for ds-83b31ef18d49
ds-83b31ef18d49 data_in PSENEN