protein

PTPRBPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTPRBPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	PTPRBPROTEIN
Protein Type	Receptor
Function	is a critical regulator of vascular development, angiogenesis, and blood-brain barrier (BBB) integrity.
Primary Expression	endothelial cells and plays essential roles in embryonic vascular development, maintaining vascular homeostasis, and regulating the neurovascular unit
Subcellular Localization	</strong></td><td>Cell membrane, endothelial junctions</td></tr>
Molecular Weight	200 kDa
Amino Acids	2135 aa
GeneCards	PTPRBPROTEIN
Human Protein Atlas	PTPRBPROTEIN
Fibronectin repeats	Mediate protein-protein interactions and adhesion properties
MAM domain	Involved in cell-cell recognition and adhesion
Phosphatase domain	Catalytically active, dephosphorylates VEGFR2, Tie2, and VE-cadherin
Dimerization	PTPRB forms homodimers at endothelial cell junctions
N-linked glycosylation	Extensive glycosylation in the extracellular domain affects protein folding and localization
Phosphorylation	Tyrosine phosphorylation regulates PTPRB activity and interactions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ptprb-protein

protein · 1843 words

→

Pathway Diagram

graph TD
    PTPRBPROTEIN["PTPRBPROTEIN"]
    neurodegeneration["neurodegeneration"]
    PTPRBPROTEIN -->|"implicated_in"| neurodegeneration
    style PTPRBPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTPRBPROTEIN in their description or question text

No additional research found