Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PV interneurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| amyloid-β oligomers | causes (specifically disrupt parvalbumin-positive interneu) | protein | 0.82 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting EC-II PV interneurons to suppress | 0.670 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop optogenetic targeting PV interneurons to restore | 0.633 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop focused ultrasound targeting CA1 PV interneurons | 0.614 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II PV interneurons to enhance | 0.578 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop focused ultrasound targeting EC-II PV interneuro | 0.568 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop transcranial focused ultrasound targeting CA1 PV | 0.508 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] | Yang S, Wang X, Yan Y, Zhang J, Wei Y et | J Affect Disord | 2026 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | Mostajo-Radji MA, Leon WRM, Breevoort A, | iScience | 2025 | 0 |
| Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475] | Bershteyn M, Zhou H, Fuentealba L, Chen | Neuron | 2025 | 0 |
| Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284] | Walsh RM, Crabtree GW, Kalpana K, Jubier | Neuron | 2025 | 0 |
| Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610] | Gelot AB, Draia-Nicolau TO, Mathieu R, S | Epilepsia | 2025 | 0 |
| Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068] | Zhang C, Xie Z, Wang N | Am J Transl Res | 2025 | 0 |
| Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040] | Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK | Autophagy | 2024 | 0 |
| Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nat Neurosci | 2024 | 0 |
| Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] | Wang W, Lu J, Pan N, Zhang H, Dai J et a | Front Immunol | 2024 | 0 |
| Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135] | Walsh RM, Crabtree GW, Kalpana K, Jubier | bioRxiv | 2024 | 0 |
| Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149] | Fogaça MV, Wu M, Li C, Li XY, Picciotto | Mol Psychiatry | 2021 | 0 |
| Identification of epilepsy-associated neuronal subtypes and gene expression unde [PMID:33028830] | Pfisterer U, Petukhov V, Demharter S, Me | Nat Commun | 2020 | 0 |
| Meta-proteomics for the discovery of protein biomarkers of beef tenderness: An o [PMID:31882086] | Picard B, Gagaoua M | Food Res Int | 2020 | 0 |
| Transcriptional and imaging-genetic association of cortical interneurons, brain [PMID:32514083] | Anderson KM, Collins MA, Chin R, Ge T, R | Nat Commun | 2020 | 0 |