Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PV interneurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| gamma oscillation generation | activates | process | 0.90 |
| gamma oscillations | regulates | process | 0.90 |
| pyramidal neuron synchronization | modulates | process | 0.90 |
| temporal coordination of pyramidal cell ensembles | regulates | process | 0.90 |
| tau propagation | regulates | process | 0.70 |
| gamma oscillations | modulates | process | 0.70 |
| gamma restoration | therapeutic_target_for | process | 0.70 |
| sharp-wave ripple generation | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| amyloid-β oligomers | causes (specifically disrupt parvalbumin-positive interneu) | protein | 0.82 |
| Piezo1 | associated_with | protein | 0.50 |
| closed-loop tACS | modulates | drug | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.575
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
| Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int | in_vivo | Alzheimer's disease | 0.765 | 0.55 | APP/PS1 mice 8-11 months (n=10 | abandoned | $125,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Retinal Müller glia alterations and their impact on ocular glymphatic clearance [PMID:41603340] | Das G, Raghunathan R, Wang L | J Alzheimers Dis | 2026 | 0 |
| The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584] | ["Costea D", "Dobrin N", "Tataru C", "To | International journal of molec | 2025 | 0 |
| Longitudinal changes of blood-brain barrier and transcytolemmal water exchange p [PMID:40089221] | Xiong C, Yu Z, Yin Y | Neuroimage | 2025 | 0 |
| The future of biomarkers for vascular contributions to cognitive impairment and [PMID:40542975] | Lennon MJ, Karvelas N, Ganesh A | Geroscience | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasou [PMID:32999351] | Lee Y, Choi Y, Park EJ | Sci Rep | 2020 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
Hypotheses and analyses mentioning PV interneurons in their description or question text
Score: 0.754 · alzheimers · 2026-04-07
## Mechanistic Overview Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-gamma coupling and
Score: 0.596 · alzheimers · 2026-04-07
## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibition and block tau
Score: 0.585 · alzheimers · 2026-04-28
PV interneurons co-release NPY, which signals via Y1 receptors on excitatory terminals to suppress glutamate release and
Score: 0.564 · alzheimers · 2026-04-20
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore Anky
Score: 0.555 · alzheimers · 2026-04-21
## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-2 expression in P
Score: 0.547 · molecular-neurobiology · 2026-04-17
## Mechanistic Overview Gamma-Entrained PV Interneurons Enable p-tau217-Guided Precision Dosing of lncRNA Therapeutics i
Score: 0.542 · alzheimers · 2026-04-21
## Mechanistic Overview Real-time closed-loop transcranial focused ultrasound targeting PV interneurons with API-integra
Score: 0.464 · molecular-neurobiology · 2026-04-21
## Mechanistic Overview Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome Therapy in Early
Score: 0.380 · molecular-neurobiology · 2026-04-26
This hypothesis proposes that lncRNA-9969's selective sequestration of miR-6361 in parvalbumin interneurons operates thr
Score: 0.380 · molecular-neurobiology · 2026-04-27
This hypothesis proposes that lncRNA-9969, when upregulated by CREB1 activation in parvalbumin (PV) interneurons, employ
Score: 0.376 · alzheimers · 2026-04-26
Parvalbumin-positive (PV) interneurons in hippocampal CA3 serve as critical theta-gamma coupling modulators that coordin