gene

PIEZO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIEZO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1011Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

PIEZO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 510 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIEZO1
Full Name	Piezo Type Mechanosensitive Ion Channel Component 1
Chromosome	16q24.3
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Small molecule modulator of mechanosensitive ion channel activity
Mechanism of Action	Small molecule modulator of mechanosensitive ion channel activity
Primary Expression	microglia, astrocytes, and brain endothelial cells, where it transduces mechanical cues from the ti
Druggability	Low (0.42)
Clinical Stage	Phase I
Molecular Weight	286 kDa
Amino Acids	521 aa
Exons	51
Pathways	Angiogenesis, Apoptosis, Autophagy, Calcium Signaling, Epigenetic
UniProt ID	Q9H5I5
NCBI Gene ID	9780
Ensembl ID	ENSG00000103335
OMIM	611184
GeneCards	PIEZO1
Human Protein Atlas	PIEZO1
Associated Diseases	Als, Alzheimer, Atherosclerosis, Bacterial Infection, Cancer, Cardiovascular
Known Drugs/Compounds	Yoda1, artemisinin, Paeoniflorin
Interactions	KCNK2, IL6, EGFR, SRC, p38, TRPC1
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Extracellular Matrix Stiffness Modulation
KG Connections	960 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: PIEZO1 — PDB 5Z10 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

gene · 1444 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    PIEZO1["PIEZO1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PIEZO1["PIEZO1"] -->|"interacts"| KCNK2["KCNK2"]
    PIEZO1["PIEZO1"] -->|"co discussed"| P2RX7["P2RX7"]
    PIEZO1["PIEZO1"] -->|"co discussed"| DGAT1["DGAT1"]
    PIEZO1["PIEZO1"] -->|"co discussed"| C3["C3"]
    PIEZO1["PIEZO1"] -->|"co discussed"| GABRA1["GABRA1"]
    KCNK2_1["KCNK2"] -->|"interacts"| PIEZO1["PIEZO1"]
    BMAL1["BMAL1"] -->|"co discussed"| PIEZO1["PIEZO1"]
    HK2["HK2"] -->|"co discussed"| PIEZO1["PIEZO1"]
    MIRO1["MIRO1"] -->|"co discussed"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (742)

Target	Relation	Type	Str
TMEM16F	interacts_with	gene	1.00
Als	activates	disease	1.00
Uterine Contractions	mediates	phenotype	0.95
Macrophage Efferocytosis	activates	process	0.95
Central Nervous System	involved_in	process	0.95
Macrophage Polarization	modulates	process	0.95
Stiffness Sensing	modulates	process	0.95
Mechanical Force Transduction	mediates	process	0.95
Muscle Mass	regulates	phenotype	0.95
Bone Mass	regulates	phenotype	0.95
Lymphatic Malformations	causes	disease	0.95
Uterine Contractions	involved_in	phenotype	0.95
Parturition	involved_in	process	0.95
Stiffness Sensing	mediates	process	0.95
Central Nervous System Physiology	regulates	process	0.95
Lymphatic Endothelial Cells	expressed_in	cell_type	0.95
Efferocytosis	activates	process	0.95
Hepatic Fibrosis	upregulates	disease	0.95
Macrophage Efferocytosis	associated_with	process	0.95
Liver Fibrosis Resolution	promotes	phenotype	0.95
Macrophage Efferocytosis	promotes	process	0.95
uterine contractions	associated_with	phenotype	0.95
mechanosensing	mediates	process	0.95
mechanical stimuli	associated_with	process	0.95
Tumor Cell Proliferation	regulates	process	0.95
Tumor Cell Migration	regulates	process	0.95
Tumor Cell Invasion	regulates	process	0.95
Tumor Angiogenesis	promotes	process	0.95
Tumor Progression	involved_in	process	0.95
Renal Fibrosis	implicated_in	disease	0.95
Mechanical Forces	involved_in	process	0.92
Tissue Stiffness	mediates	phenotype	0.92
Liver Fibrosis	protects_against	disease	0.92
parturition	mediates	process	0.92
liver fibrosis	therapeutic_target	disease	0.92
calcium influx	causes	phenotype	0.90
bone formation	activates	phenotype	0.90
bone mass	contributes_to	phenotype	0.90
podocyte injury	causes	phenotype	0.90
adipogenesis	activates	phenotype	0.90
FGF1	causes	protein	0.90
macrophage polarization	regulates	phenotype	0.90
Labor Progression	associated_with	process	0.90
Periodontal Ligament Cells	expressed_in	cell_type	0.90
Liver Fibrosis	treats	disease	0.90
Mechanobiology	mediates	process	0.90
Calcium Influx	mediates	process	0.90
Efferocytosis	associated_with	biological_process	0.90
Liver Fibrosis	associated_with	disease	0.90
Cell Cycle Progression	regulates	process	0.90

Incoming (269)

Source	Relation	Type	Str
Mechanical Stimulation	activates	mechanism	0.95
Paeoniflorin	binds	compound	0.95
NF-κB	upstream_of	pathway	0.95
Paeoniflorin	therapeutic_target	compound	0.93
IL1A	activates	protein	0.90
CREB1	regulates	protein	0.90
mechanical loading	activates	phenotype	0.90
tissue stiffness	activates	phenotype	0.90
artemisinin	inhibits	drug	0.90
Mechanical Stretch	activates	process	0.90
TNF	upregulates	entity	0.90
Tissue Stiffening	upregulates	process	0.90
Tissue Stiffness	activates	phenotype	0.90
ECM stiffness	activates	phenotype	0.90
h-725c62e9	targets_gene	hypothesis	0.90
HNF4	regulates	protein	0.80
ATF2	regulates	protein	0.80
diabetic kidney disease	activates	disease	0.80
h-db6aa4b1	targets	hypothesis	0.80
h-725c62e9	targets	hypothesis	0.80
FAM38A	encodes	gene	0.80
p38 MAPK	regulates	protein	0.80
Inflammation	modulates	process	0.75
MECHANICAL_STIMULATION	activates	phenotype	0.72
Yoda1	activates	drug	0.72
high fat diet	activates	phenotype	0.70
BAX	activates	gene	0.70
RUNX2	activates	gene	0.70
cyclical_hydrostatic_pressure	activates	phenotype	0.64
KCNK2	co_mentioned_with	gene	0.60
JUN	activates	gene	0.60
TAZ	protects_against	gene	0.60
ORAI1	regulates	gene	0.60
EGF	activates	gene	0.60
CACNA1B	associated_with	gene	0.60
CACNA1C	expressed_in	gene	0.60
CFTR	associated_with	gene	0.60
TRPV4	expressed_in	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
TRPA1	expressed_in	gene	0.60
TRPC1	activates	gene	0.60
TRPA1	regulates	gene	0.60
PIEZO2	activates	gene	0.60
PIEZO2	regulates	gene	0.60
P38	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Extracellular Matrix Stiffness Modulation	0.427	neurodegeneration	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (2)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.554

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720]	Harraz OF, Hashad AM	Physiology (Bethesda)	2026	1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160]	Wang Y, Wang J, Zhang J, Wang Y, Wang Y,	Sci Adv	2024	1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007]	Zong B, Yu F, Zhang X, Pang Y, Zhao W, S	Ageing Res Rev	2023	1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296]	Jiang Y, Zhang H, Wang J, Liu Y, Luo T,	J Hematol Oncol	2022	1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671]	Atcha H, Jairaman A, Holt JR, Meli VS, N	Nat Commun	2021	1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920]	Sun H, Wu Z, Zhang Y, Liu C, Gao D et al	Osteoarthritis Cartilage	2026	0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513]	Ma J, Xie N, Wang Z, Liang X, Han Y et a	Adv Sci (Weinh)	2026	0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798]	Zhang M, Ge Y, Wang Z, Li H, Wang G et a	Neurosci Biobehav Rev	2026	0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045]	Pillai EK, Mukherjee S, Gampl N, McGinn	Nat Mater	2026	0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354]	Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a	MedComm (2020)	2026	0
Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for All [PMID:41933910]	Wolters A, Signorelli L, Herff C, Gimple	Adv Sci (Weinh)	2026	0
A 3D-Printed Pulsatile Shear Stress Platform for Studying Endothelial Cell Mecha [PMID:41949555]	Romanov V, Li JV, Zhao F, Cheng D, Marti	Anal Chem	2026	0
Piezo channels in tumors. [PMID:41964669]	Zhang W, Dai L, Shi H	J Cancer Res Clin Oncol	2026	0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265]	["Li R", "Xia J", "Shi C", "Zhang K", "Q	Journal of advanced research	2026	0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938]	Wang H, Gou Z, Chen S, Lu L	The International journal of n	2026	0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420]	Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li	Frontiers in molecular bioscie	2025	0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683]	Gupta T, Singh TG, Singh R	Molecular biology reports	2025	0
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281]	Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi	Cell	2024	0
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing nov [PMID:35236990]	["Costello S", "Shoemaker S", "Hobbs H",	Nature structural & molecular	2022	0
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hep [PMID:36181398]	Li M, Zhang X, Wang M, Wang Y, Qian J, X	Cancer communications (London,	2022	0

PIEZO1

Understanding Entity Pages

Summary

Wiki Pages (21)

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Astrocyte Reactivity Mechanism

Sulforaphane and Nrf2 Activation for Neuroprotection

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

Section 147: Telehealth and Remote Monitoring in CBS/PSP

Ferroptosis in Alzheimer's Disease

Section 233: Advanced Virtual Reality and Immersive Technology-Based Rehabilitation in CBS/PSP

O-GlcNAcase (OGA) Inhibitor Landscape — Programs, Mechanisms, Companies

Exosome and Extracellular Vesicle Brain Delivery

Ferroptosis in Neurodegeneration

Section 156: Pet Therapy and Animal-Assisted Interventions in CBS/PSP

Longevity and Rejuvenation Therapies Landscape

Astrocyte Metabolic Enhancement Therapy for PD

Section 151: Advanced Wearable and Sensor Technologies in CBS/PSP

Section 249: Advanced LSVT Voice and Speech Therapy in CBS/PSP

N-of-1 and Personalized Clinical Trial Design for CBS/PSP

ion-channel-dysfunction-disease-comparison

potassium-channel-openers-parkinsons

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)