Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Plasticity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| 21331251 | is a site of | paper | 0.90 |
| Perineuronal Nets | associated_with | structure | 0.90 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Synaptic plasticity and protein expression analysis in mPFC | exploratory | insomnia-anxiety comorbidity | 0.850 | 0.00 | mPFC brain slices from PCPA-tr | proposed | N/A |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.509 | 0.50 | human postmortem brain tissue | proposed | $520,000 |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Oscillation Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Circadian Dysfunction as Driver of Neurodegeneration | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep Disruption and Alzheimer's Disease — mechanism and intervention | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Neural Stem Cell Therapy for Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neuron type-specific optogenetic stimulation for differential stroke recovery in [PMID:38825647] | Kim RG, Cho J, Park JY, Kim YR, Lee MC, | Exp Mol Med | 2024 | 1 |
| Optogenetic control of nerve growth. [PMID:25982506] | Park S, Koppes RA, Froriep UP, Jia X, Ac | Sci Rep | 2015 | 1 |
| Effects of caffeine on sleep and cognition. [PMID:21531247] | Snel J, Lorist MM | Prog Brain Res | 2011 | 1 |
| Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808] | Kunttas-Tatli E, Bose A, Kahali B, Bisho | Genesis | 2009 | 1 |
| CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970] | Lu W, Kawatani K, Ren Y | Alzheimers Res Ther | 2026 | 0 |
| Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536] | Zheng ZW, Min PX, Luo YL, Mao XF, Zhang | Neuron | 2026 | 0 |
| Optogenetic approaches for neural tissue regeneration: A review of basic optogen [PMID:39995064] | ["Eldar D", "Albert S", "Tatyana A", "Ga | Neural regeneration research | 2026 | 0 |
| Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108] | Pruitt A, Yang L, Lee S, Balafkan N, Sea | bioRxiv : the preprint server | 2026 | 0 |
| A wireless optogenetic stimulation system for long-term function evaluation of m [PMID:41027946] | ["Zhou M", "Yan B", "Yang F", "Chen C", | Nature communications | 2025 | 0 |
| Neural Circuit Mapping and Neurotherapy-Based Strategies. [PMID:40715588] | ["Marei H"] | Cellular and molecular neurobi | 2025 | 0 |
| Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasti [PMID:39662631] | ["Chen Y", "Mao L", "Zhou Q", "Bai D", " | Brain research bulletin | 2025 | 0 |
| Advances in sciatic nerve regeneration: A review of contemporary techniques. [PMID:40475697] | ["Ali S", "Sun M", "Khan M", "Qiang F"] | Regenerative therapy | 2025 | 0 |
| Untitled [PMID:38753056] | ["Wang H", "Huang Z", "Lou S", "Li W", " | Chemical research in toxicolog | 2024 | 0 |
| Electrical Stimulation: How It Works and How to Apply It. [PMID:38972685] | ["Senger J", "Power H", "Moore A"] | Hand clinics | 2024 | 0 |
| Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced [PMID:39561026] | ["Chen B", "Sun Y", "Sun H", "Cong N", " | ACS nano | 2024 | 0 |
| Enhancing Motor and Sensory Axon Regeneration after Peripheral Nerve Injury Usin [PMID:36555724] | ["Ecanow A", "Berglund K", "Carrasco D", | International journal of molec | 2022 | 0 |
| Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098] | ["Oristrell J", "Oliva J", "Casado E", " | Journal of endocrinological in | 2022 | 0 |
| The impact of acupuncture on neuroplasticity after ischemic stroke: a literature [PMID:36439200] | ["Qin S", "Zhang Z", "Zhao Y", "Liu J", | Frontiers in cellular neurosci | 2022 | 0 |
| Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388] | Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y, | Seizure | 2022 | 0 |
| Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341] | Rátkai A, Tárnok K, Aouad HE, Micska B, | Scientific reports | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Plasticity in their description or question text
Score: 0.530 · neurodegeneration · 2026-04-25
Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes
Score: 0.515 · neurodegeneration · 2026-04-02
## Mechanistic Overview Vocal Cord Neuroplasticity Stimulation starts from the claim that modulating CHR2/BDNF within th
Score: 0.512 · methodology · 2026-04-12
## Mechanistic Overview Neuroplasticity-Enhanced Learning Hypothesis starts from the claim that modulating BDNF within t
Score: 0.455 · clinical-neurology · 2026-04-27
Low-level TNF-α/IL-6 signaling is essential for synaptic scaling and homeostatic plasticity in AD brains attempting comp
Score: 0.455 · neuroinflammation · 2026-04-27
After acute cerebrovascular events, persistent SPI1 activity maintains microglia in pro-inflammatory states that inhibit
Score: 0.000 · unknown disease · 2026-04-28
Pharmacological enhancement of sleep-dependent synaptic plasticity processes to restore the restorative functions of sle
Score: 0.000 · unknown disease · 2026-04-28
Transcranial stimulation protocols targeting motor cortex plasticity, combined with proprioceptive training, to strength