Q16539

Understanding Entity Pages

This page aggregates everything SciDEX knows about Q16539: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

p38 MAPK Protein (p38 Alpha)

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graph TD
    MAPK14["MAPK14/p38 MAPK"]
    Q16539["MAPK8IP1/JIP1"]
    JNK1["JNK1/MAPK8"]
    JNK2["JNK2/MAPK9"]
    JNK3["JNK3/MAPK10"]
    APP["Amyloid Precursor Protein"]
    TAU["Tau Protein"]
    CASP3["Caspase-3"]
    APOPTOSIS["Neuronal Apoptosis"]
    OXIDATIVE["Oxidative Stress"]
    INFLAMMATION["Neuroinflammation"]
    ALZHEIMER["Alzheimer Disease"]
    PARKINSON["Parkinson Disease"]
    NEUROPROTECTION["Neuroprotective Signaling"]
    SYNAPTIC["Synaptic Dysfunction"]
    
    MAPK14 -->|"activates"| Q16539
    Q16539 -->|"scaffolds"| JNK1
    Q16539 -->|"scaffolds"| JNK2
    Q16539 -->|"scaffolds"| JNK3
    JNK1 -->|"phosphorylates"| TAU
    JNK2 -->|"phosphorylates"| APP
    JNK3 -->|"activates"| CASP3
    TAU -->|"hyperphosphorylation"| ALZHEIMER
    APP -->|"amyloidogenic processing"| ALZHEIMER
    CASP3 -->|"executes"| APOPTOSIS
    OXIDATIVE -->|"activates"| MAPK14
    INFLAMMATION -->|"activates"| MAPK14
    APOPTOSIS -->|"contributes to"| PARKINSON
    APOPTOSIS -->|"contributes to"| ALZHEIMER
    Q16539 -->|"modulates"| NEUROPROTECTION
    JNK1 -->|"impairs"| SYNAPTIC
    
    style Q16539 fill:#1a3a4a,stroke:#4fc3f7
    style NEUROPROTECTION fill:#1a3a2a,stroke:#81c784
    style MAPK14 fill:#2a1a3a,stroke:#ce93d8
    style JNK1 fill:#2a1a3a,stroke:#ce93d8
    style JNK2 fill:#2a1a3a,stroke:#ce93d8
    style JNK3 fill:#2a1a3a,stroke:#ce93d8
    style APOPTOSIS fill:#3a1a1a,stroke:#ef5350
    style OXIDATIVE fill:#3a1a1a,stroke:#ef5350
    style INFLAMMATION fill:#3a1a1a,stroke:#ef5350
    style SYNAPTIC fill:#3a1a1a,stroke:#ef5350
    style ALZHEIMER fill:#3a2a1a,stroke:#ffa726
    style PARKINSON fill:#3a2a1a,stroke:#ffa726