gene

MAPK14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

732Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MAPK14 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK14
Full Name	Mitogen-Activated Protein Kinase 14 (p38α)
Chromosome	6p21.3
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase belonging to the MAPK family.
Molecular Weight	41 kDa
Amino Acids	360 aa
Pathways	MAPK, TGF-β
UniProt ID	[Q16539](https://www.uniprot.org/uniprot/Q16539)
Ensembl ID	ENSG00000166401
OMIM	600289
GeneCards	MAPK14
Human Protein Atlas	MAPK14
Associated Diseases	Aging, Als, Cancer, Cardiovascular, Ischemia, Ms
Known Drugs/Compounds	Losmapimod, rapamycin
Interactions	AIFM1, AKT1, AKT1S1, ALZHEIMER, AMBRA1, AMPK
KG Connections	732 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)

gene · 1381 words

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MAPK14 Protein

protein · 911 words

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Pathway Diagram

graph TD
    MAPK14["MAPK14"] -->|"Inhibits"| TTP["TTP"]
    MAPK14["MAPK14"] -->|"Interacts With"| Cancer["Cancer"]
    MAPK14["MAPK14"] -->|"Interacts With"| Als["Als"]
    MAPK14["MAPK14"] -->|"Interacts With"| Ms["Ms"]
    MAPK14["MAPK14"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    MAPK14["MAPK14"] -->|"Therapeutic Target"| Osteoporosis["Osteoporosis"]
    MAPK14["MAPK14"] -->|"Interacts With"| BECN1["BECN1"]
    MAPK14["MAPK14"] -->|"Interacts With"| ATF6["ATF6"]
    OPTN["OPTN"] -->|"Interacts With"| MAPK14["MAPK14"]
    CASP3["CASP3"] -->|"Interacts With"| MAPK14["MAPK14"]
    AKT1["AKT1"] -->|"Interacts With"| MAPK14["MAPK14"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| MAPK14["MAPK14"]
    CGAS["CGAS"] -->|"Interacts With"| MAPK14["MAPK14"]
    style MAPK14 fill:#8d4900,color:#e0e0e0
    style TTP fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Osteoporosis fill:#b71c1c,color:#e0e0e0
    style BECN1 fill:#8d4900,color:#e0e0e0
    style ATF6 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (416)

Target	Relation	Type	Str
TDP-43 Phosphorylation	phosphorylates	process	0.95
TDP-43 Proteinopathy	contributes_to	disease	0.95
Neurodegeneration	involved_in	process	0.90
SNCA_S129	phosphorylates	protein	0.90
MAPT	phosphorylates	protein	0.90
TTP	inhibits	protein	0.90
ER Stress Response	mediates	process	0.87
TNF Signaling Pathway	component_of	pathway	0.85
Osteoclast Differentiation	involved_in	process	0.85
Autophagy	inhibits	process	0.85
DUX4	regulates	gene	0.85
Tau Phosphorylation	mediates	process	0.85
Neuroinflammation	involved_in	process	0.85
MAPK signaling	participates_in	pathway	0.80
cellular senescence	regulates	process	0.80
Mapk	therapeutic_target	pathway	0.70
GENES	biomarker_for	gene	0.70
Mapk	regulates	pathway	0.70
Q16539	activates	protein	0.70
Als	associated_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Infection	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Fibrosis	regulates	disease	0.65
Als	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Sepsis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Sepsis	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Osteoporosis	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65

Incoming (316)

Source	Relation	Type	Str
Ros	activates	phenotype	0.90
h-ccc05373	targets_gene	hypothesis	0.90
Losmapimod	inhibits	drug	0.90
MKK6	activates	protein	0.90
KDEL	activates	receptor	0.90
Cholix	phosphorylates	entity	0.85
SRC	interacts_with	gene	0.80
MMP9	therapeutic_target	gene	0.70
AKT1	targets	gene	0.70
TNF	therapeutic_target	gene	0.70
TAB1	activates	protein	0.70
IL1B	targets	gene	0.70
MAP2K3_MAP2K6	phosphorylates	protein	0.70
SQSTM1	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
P38	activates	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
SRC	associated_with	gene	0.60
PRDX6	activates	gene	0.60
ERN1	interacts_with	gene	0.60
CHUK	activates	gene	0.60
IGF1R	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
RXRA	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
TRAF6	activates	gene	0.60
JUN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows PSEN2 is essential in cortical and dopaminergic neurons and regu

closed · Rounds: 4 · Score: 0.68 · 2026-04-16

Related Research

Hypotheses and analyses mentioning MAPK14 in their description or question text

No additional research found