gene

RAB15

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RAB15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RAB15

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🧬 Gene Info

Gene Symbol	RAB15
Function	RAB15 is a brain-enriched Rab GTPase that plays crucial roles in synaptic vesicle endocytosis and recycling.
Ensembl ID	ENSG00000139836
GeneCards	RAB15
Human Protein Atlas	RAB15
Synaptic Vesicle Endocytosis	Rab15 specifically regulates clathrin-mediated endocytosis at presynaptic terminals [@clathrinmediated2017]
Vesicle Recycling	Coordinates the recycling of synaptic vesicles after neurotransmitter release
Neurotransmitter Receptor Trafficking	Regulates the endocytosis and recycling of AMPA and NMDA receptors at postsynaptic sites [@postsynaptic2019]
Early Endosome Function	Controls the maturation and sorting of early endosomes in neurons
Synaptic Vesicle Replenishment	Essential for rapid recycling of synaptic vesicles during sustained neuronal activity
Postsynaptic Receptor Turnover	Regulates the replacement of synaptic receptors during synaptic plasticity
Axon Initial Segment Function	Important for maintaining protein composition at the axon initial segment
Dendritic Spine Endocytosis	Facilitates clathrin-mediated endocytosis in dendritic spines [@dendritic2020]
Striatum	Medium spiny neurons
Cerebellum	Purkinje cells
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

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Canonical Page

RAB15

gene · 765 words

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Pathway Diagram

graph TD
    RAB15["RAB15"]
    neurodegeneration["neurodegeneration"]
    RAB15 -->|"implicated_in"| neurodegeneration
    style RAB15 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RAB15 in their description or question text

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