Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB43 - small GTPase involved in intracellular membrane trafficking, implicated in Parkinson's disease and lysosomal function
| Gene Symbol | RAB43 |
| Full Name | RAB43 |
| Chromosome | 7q21.3 |
| Protein Type | Gene |
| Function | is a member of the RAB GTPase family of small GTP-binding proteins that function as molecular switches in intracellular membrane trafficking. |
| Subcellular Localization | , predominantly associated with the Golgi apparatus and endosomal compartments. This localization is mediated by specifi |
| Molecular Weight | 24 kDa |
| Amino Acids | 215 aa |
| Exons | 6 |
| UniProt ID | Q86YS7 |
| NCBI Gene ID | 201164 |
| Ensembl ID | ENSG00000137601 |
| GeneCards | RAB43 |
| Human Protein Atlas | RAB43 |
| Associated Diseases | Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB43["RAB43"]
neurodegeneration["neurodegeneration"]
RAB43 -->|"implicated_in"| neurodegeneration
style RAB43 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity