gene

RAB6A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB6A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

RAB6A

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RAB6A
Function	RAB6A is a Golgi-resident small GTPase that regulates retrograde transport from the Golgi to the endoplasmic reticulum (ER).
Primary Expression	motor neurons, which are selectively affected in ALS
Ensembl ID	ENSG00000168244
GeneCards	RAB6A
Human Protein Atlas	RAB6A
Retrograde Transport	Rab6A coordinates the retrieval of cargo from the Golgi back to the ER, a fundamental process for maintaining ER-Golgi homeostasis [@golgier2017]
Golgi Organization	The protein maintains Golgi stack morphology and function through regulation of COPI vesicle trafficking
Vesicle Tethering	Rab6A interacts with effector proteins including p115, GM130, and GRASP65 to tether vesicles to their correct destinations
Cytoskeletal Regulation	Rab6A modulates microtubule-based transport and interacts with dynein/dynactin motor complexes [@raba2019]
Synaptic Vesicle Recycling	Rab6A regulates the retrieval of synaptic vesicle components after neurotransmitter release
Protein Quality Control	The Golgi-ER retrieval pathway is essential for disposing of misfolded proteins and maintaining proteostasis
Axonal Transport	Rab6A-mediated trafficking is crucial for transporting proteins along axons and dendrites
Dendritic Spine Morphogenesis	Rab6A function influences the formation and maintenance of dendritic spines [@rab2020a]
Brain	Particularly in neurons of the basal ganglia, hippocampus, cerebral cortex, and motor neurons of the spinal cord
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB6A

gene · 977 words

→

Pathway Diagram

graph TD
    RAB6A["RAB6A"]
    neurodegeneration["neurodegeneration"]
    RAB6A -->|"implicated_in"| neurodegeneration
    style RAB6A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB6A in their description or question text

No additional research found