gene

RAB6B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RAB6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RAB6B

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🧬 Gene Info

Gene Symbol	RAB6B
Function	RAB6B is a brain-specific isoform of RAB6A, with over 90% sequence identity, but with distinct neuronal expression patterns and functions.
Ensembl ID	ENSG00000154917
GeneCards	RAB6B
Human Protein Atlas	RAB6B
Dendritic Protein Trafficking	Rab6B specifically regulates the trafficking of proteins in dendrites, including neurotransmitter receptors and synaptic proteins [@regulation2017]
Retrograde Transport	Coordinates retrieval of cargo from the Golgi to the ER in neuronal processes
Synaptic Protein Delivery	Essential for delivering newly synthesized synaptic proteins to dendritic spines
Dendritic Golgi Outposts	Maintains Golgi outposts in dendrites that support local protein synthesis and trafficking [@local2019]
Synaptic Plasticity	Regulates the delivery and turnover of synaptic proteins during long-term potentiation (LTP) and long-term depression (LTD)
Dendritic Spine Maintenance	Essential for maintaining dendritic spine morphology and function
Local Protein Synthesis	Supports dendritic protein synthesis through trafficking of translation components
Neurotransmitter Receptor Trafficking	Regulates the surface expression of AMPA and NMDA receptors [@ampa2020]
Cerebellum	Particularly enriched in Purkinje cells
Hippocampus	High expression in CA1 pyramidal neurons and dentate gyrus granule cells
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB6B

gene · 797 words

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Pathway Diagram

graph TD
    RAB6B["RAB6B"]
    neurodegeneration["neurodegeneration"]
    RAB6B -->|"implicated_in"| neurodegeneration
    style RAB6B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RAB6B in their description or question text

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