gene

RASGRF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RASGRF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

RASGRF1 (Ras-GRF1) is a calcium/calmodulin-regulated guanine nucleotide exchange factor that activates Ras, Ras-related proteins, and Rho GTPases, critical for synaptic plasticity and memory formation.

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🧬 Gene Info

Gene Symbol	RASGRF1
Full Name	Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1
Aliases	Ras-GRF1
Function	is a calcium/calmodulin-regulated guanine nucleotide exchange factor (GEF) that activates Ras, Ras-related proteins, and Rho GTPases.
Primary Expression	the brain, particularly in the hippocampus and cortex, where it plays essential roles in learni
Molecular Weight	145 kDa
Amino Acids	262 aa
Ensembl ID	ENSG00000047293
GeneCards	RASGRF1
Human Protein Atlas	RASGRF1
RASGRP1	related but distinct family
RASGRP2	distinct
Calmodulin-binding domain (CaMBD)	calcium/calmodulin regulation
IQ motifs	calmodulin interaction sites
DH domain	Rho-specific GEF activity
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

gene · 3044 words

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RASGRF1 Protein — Ras-GRF1

protein · 1860 words

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Pathway Diagram

graph TD
    RASGRF1["RASGRF1"]
    neurodegeneration["neurodegeneration"]
    RASGRF1 -->|"implicated_in"| neurodegeneration
    style RASGRF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RASGRF1 in their description or question text

No additional research found