gene 3,044 words KG: RASGRF1 2026-03-27
kind:genesection:genesstate:published
Contents

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

🧬 Gene Info
Gene SymbolRASGRF1
Full NameRas Protein-Specific Guanine Nucleotide-Releasing Factor 1
AliasesRas-GRF1
Functionis a calcium/calmodulin-regulated guanine nucleotide exchange factor (GEF) that activates Ras, Ras-related proteins, and Rho GTPases.
Primary Expressionthe brain, particularly in the hippocampus and cortex, where it plays essential roles in learni
Molecular Weight145 kDa
Amino Acids262 aa
Ensembl IDENSG00000047293
GeneCardsRASGRF1
Human Protein AtlasRASGRF1
RASGRP1related but distinct family
RASGRP2distinct
Calmodulin-binding domain (CaMBD)calcium/calmodulin regulation
IQ motifscalmodulin interaction sites
DH domainRho-specific GEF activity
Associated Diseasesneurodegeneration
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (9)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

RASGRF1 provides_data_for ds-83b31ef18d49
ds-83b31ef18d49 data_in RASGRF1