Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RASP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RASP |
| Function | As with other Ras family members, this cycling regulates its ability to interact with downstream effectors. |
| Primary Expression | Purkinje cells and granule cells - Substantia Nigra: Present in dopaminergic neurons - Basal Ganglia: Expression in striatal medium spiny neur |
| Amino Acids | 276 aa |
| Ensembl ID | ENSG00000113595 |
| GeneCards | RASP |
| Human Protein Atlas | RASP |
| Brain-enriched expression | Highest expression in the cerebral cortex, hippocampus, and cerebellum |
| Activity-dependent regulation | Expression and activation are modulated by neuronal activity |
| Synaptic localization | Enriched at synaptic terminals, particularly in postsynaptic densities |
| Long-term potentiation (LTP) | RASP1 signaling contributes to LTP induction and maintenance in hippocampal neurons |
| Long-term depression (LTD) | Involved in AMPA receptor internalization during LTD |
| NMDA receptor signaling | Interacts with NMDA receptor subunits to mediate activity-dependent signaling [@wang2011] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RASP["RASP"]
neurodegeneration["neurodegeneration"]
RASP -->|"implicated_in"| neurodegeneration
style RASP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RASP in their description or question text
No additional research found