Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGS10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Regulator of G protein signaling 10, a GTPase-activating protein involved in neuroinflammation, dopaminergic signaling, and microglial activation in neurodegenerative diseases.
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| Gene Symbol | RGS10 |
| Full Name | Regulator of G Protein Signaling 10 |
| Chromosome | 10q26.11 |
| Function | encodes a member of the RGS family of GTPase-activating proteins that negatively regulate G protein-coupled receptor (GPCR) signaling. |
| Primary Expression | both neuronal and glial populations [7]: |
| Subcellular Localization | and function. The RGS domain adopts a characteristic alpha-helical bundle structure that mediates binding to active Gα s |
| Amino Acids | 180 aa |
| UniProt ID | Q9NS28 |
| NCBI Gene ID | 6004 |
| Ensembl ID | ENSG00000148991 |
| OMIM | 602866 |
| GeneCards | RGS10 |
| Human Protein Atlas | RGS10 |
| Cerebral Cortex | Moderate to high expression in cortical layers, particularly layer V pyramidal neurons |
| Hippocampus | High expression in CA1-CA3 pyramidal neurons and dentate gyrus granule cells |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RGS10["RGS10"]
neurodegeneration["neurodegeneration"]
RGS10 -->|"implicated_in"| neurodegeneration
style RGS10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RGS10 in their description or question text
No additional research found